Maxillofacial Unit, Royal Brisbane Hospital, Herston 4029, QLD, Australia.
Int J Oral Maxillofac Surg. 2012 Jan;41(1):2-4. doi: 10.1016/j.ijom.2011.06.018. Epub 2011 Jul 22.
Osteoradionecrosis of the jaws is a complication of radiotherapy and controversy remains about the management of teeth in the field of radiotherapy. Platelet rich plasma has been advocated in multiple surgical sites, both bone and soft tissue, to promote healing and reduce complications. A randomized double blinded controlled trial was performed on patients receiving bilateral radiotherapy that affected the mandible who required pre treatment dental extractions. One side received platelet rich plasma and the other acted as a control. Twenty-two patients were recruited over 12 months and over a 5-year period following treatment three developed osteoradionecrosis (14%). Platelet rich plasma failed to show any benefit in the prevention of osteoradionecrosis. Nor was there any benefit in pain scores or mucosal healing on sides that were treated with platelet rich plasma. Platelet rich plasma fails to show a benefit in the prevention of osteoradionecrosis. The rate of osteoradionecrosis is high compared to other published series and the prophylactic removal of molar teeth should be questioned as a preventative measure.
颌骨放射性骨坏死是放射治疗的一种并发症，关于放射治疗领域的牙齿处理仍存在争议。富含血小板的血浆已在多个手术部位（包括骨骼和软组织）中被提倡用于促进愈合和减少并发症。对接受双侧放射治疗影响下颌骨且需要治疗前拔牙的患者进行了一项随机双盲对照试验。一侧接受富含血小板的血浆治疗，另一侧作为对照。在 12 个月和 5 年的治疗随访期间，共招募了 22 名患者，有 3 名患者发生放射性骨坏死（14%）。富含血小板的血浆未能显示出预防放射性骨坏死的任何益处。在接受富含血小板的血浆治疗的一侧，疼痛评分或粘膜愈合也没有任何益处。富含血小板的血浆未能显示出预防放射性骨坏死的益处。与其他已发表的系列相比，放射性骨坏死的发生率较高，预防性拔除磨牙作为预防措施应受到质疑。
