Clinical Microbiology & Public Health Laboratory, Peterborough & Stamford Hospitals NHS Foundation Trust, Peterborough City Hospital, Bretton Gate, Peterborough PE3 9GW, UK.
Int J Antimicrob Agents. 2011 Dec;38(6):465-73. doi: 10.1016/j.ijantimicag.2011.05.010. Epub 2011 Jul 22.
Posaconazole (PCZ) is an orally administered, extended-spectrum triazole antifungal agent with activity against the Mucorales. This article describes the clinical and laboratory data supporting its use against this rare group of pathogens. To date, PCZ has been mostly used for salvage therapy and at present there is no strong published clinical evidence to support its role as a single agent in the treatment of mucormycosis. Further studies are required to explore its role as a single agent and in combination therapy for the management of these infections.
泊沙康唑（PCZ）是一种口服、广谱三唑类抗真菌药物，对毛霉目真菌具有活性。本文介绍了支持其用于治疗此类罕见病原体的临床和实验室数据。迄今为止，PCZ 主要用于挽救治疗，目前尚无强有力的临床证据支持其作为单一药物治疗毛霉菌病。需要进一步研究来探索其作为单一药物和联合治疗这些感染的作用。
