Reid H W, Buxton D, Finlayson J, Holmes P H
Infect Immun. 1979 Feb;23(2):192-6. doi: 10.1128/iai.23.2.192-196.1979.
The course of louping-ill virus infection in mice chronically infected with Trypanosoma brucei was investigated. The mean survival time of mice infected with virus alone was 10.2 days, compared to 12.8 days in mice infected with T. brucei 14 days before virus challenge, and the cumulative mortality in the two groups was 62.5 and 90%, respectively. Virus was only inconsistently detected in the blood of mice given virus alone but was regularly present at high titers for up to 12 days in the blood of mice previously infected with T. brucei. Titers of virus in brains were also higher in dually infected mice, and encephalitis was of greater severity. These results indicate that the immunosuppressive effect of chronic trypanosomiasis may markedly increase susceptibility to acute virus infection. In addition, it is concluded that vector-vertebrate relationships of arthropod-transmitted viruses may be altered by concurrent trypanosome infection.
对慢性感染布氏锥虫的小鼠感染跳跃病病毒的病程进行了研究。单独感染病毒的小鼠平均存活时间为10.2天,而在病毒攻击前14天感染布氏锥虫的小鼠平均存活时间为12.8天,两组的累积死亡率分别为62.5%和90%。单独给予病毒的小鼠血液中仅偶尔检测到病毒,但先前感染布氏锥虫的小鼠血液中病毒在长达12天的时间里持续以高滴度存在。双重感染小鼠大脑中的病毒滴度也更高,且脑炎更为严重。这些结果表明,慢性锥虫病的免疫抑制作用可能显著增加对急性病毒感染的易感性。此外,得出的结论是,同时感染锥虫可能会改变节肢动物传播病毒的媒介与脊椎动物之间的关系。