Pharmaceutical Sciences Research Institute, Aston University, Aston Triangle, Birmingham B4 7ET, UK.
Environ Toxicol Pharmacol. 2001 Sep;10(4):173-82. doi: 10.1016/s1382-6689(01)00081-3.
Ascorbic acid (AA) is an essential micronutrient for man, with many biological roles. It is a powerful antioxidant both directly via scavenging of reactive oxygen species and indirectly through regeneration of other antioxidant systems. Paradoxically, under certain conditions (low concentration in vitro, presence of metal ions) it can exert a pro-oxidant effect, increasing oxidative damage to lipids, DNA and protein. Herein, the effects of vitamin C both in vitro and in vivo are addressed in terms of modulation of oxidative DNA damage, gene expression and protein oxidation. The view of AA as a simple scavenger is outdated, where the arrival of new bioinformatic techniques, heralds a new dawning in our understanding of ascorbate as a potential direct or indirect modulator of gene expression.
抗坏血酸（AA）是人类必需的微量营养素，具有许多生物学作用。它是一种强大的抗氧化剂，既能直接通过清除活性氧自由基，也能间接通过再生其他抗氧化系统来发挥作用。矛盾的是，在某些条件下（体外浓度低、存在金属离子），它会产生促氧化剂效应，增加对脂质、DNA 和蛋白质的氧化损伤。本文从氧化 DNA 损伤、基因表达和蛋白质氧化的角度，探讨了维生素 C 在体外和体内的作用。AA 作为一种简单的清除剂的观点已经过时，随着新的生物信息学技术的出现，我们对抗坏血酸作为潜在的直接或间接基因表达调节剂的理解将迎来新的曙光。
