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二芳基庚烷类化合物对白血病细胞的细胞毒性和抗增殖作用。

Cytotoxic and Antiproliferative Effects of Diarylheptanoids Isolated from Rhizomes on Leukaemic Cells.

机构信息

Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.

Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand.

出版信息

Molecules. 2020 Nov 23;25(22):5476. doi: 10.3390/molecules25225476.

DOI:10.3390/molecules25225476
PMID:33238470
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7700379/
Abstract

belongs to the Zingiberaceae family. In this study, two natural compounds were isolated from , and their structures were determined using nuclear magnetic resonance. The isolated compounds were identified as 7-(3,4-dihydroxyphenyl)-5-hydroxy-1-phenyl-(1)-1-heptene () and -1,7-diphenyl-5-hydroxy-1-heptene (). Compound showed the strongest cytotoxicity effect against HL-60 cells, while its antioxidant and anti-inflammatory properties were stronger than those of compound . Compound proved to be a potent antioxidant, compared to ascorbic acid. Neither compounds had any effect on red blood cell haemolysis. Furthermore, compound significantly decreased Wilms' tumour 1 protein expression and cell proliferation in KG-1a cells. Compound decreased the WT1 protein levels in a time- and dose- dependent manner. Compound suppressed cell cycle at the S phase. In conclusion, compound has a promising chemotherapeutic potential against leukaemia.

摘要

它属于姜科。在这项研究中，从 中分离出两种天然化合物，并通过核磁共振确定了它们的结构。分离得到的化合物被鉴定为 7-(3,4-二羟基苯基)-5-羟基-1-苯基-(1)-1-庚烯（）和-1,7-二苯基-5-羟基-1-庚烯（）。化合物 对 HL-60 细胞表现出最强的细胞毒性作用，而其抗氧化和抗炎特性强于化合物 。与抗坏血酸相比，化合物 被证明是一种有效的抗氧化剂。这两种化合物对红细胞溶血均无影响。此外，化合物 可显著降低 KG-1a 细胞中 Wilms'肿瘤 1 蛋白的表达和细胞增殖。化合物 呈时间和剂量依赖性降低 WT1 蛋白水平。化合物 可抑制细胞周期进入 S 期。总之，化合物 对白血病具有有前途的化疗潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be1e/7700379/934fc582e2a5/molecules-25-05476-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be1e/7700379/a7708decfeca/molecules-25-05476-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be1e/7700379/d181dc57ef4c/molecules-25-05476-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be1e/7700379/0eab26b282bf/molecules-25-05476-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be1e/7700379/62ca08d1d065/molecules-25-05476-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be1e/7700379/3c2ce26879f3/molecules-25-05476-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be1e/7700379/f16b29ec6095/molecules-25-05476-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be1e/7700379/05f2c7d90d56/molecules-25-05476-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be1e/7700379/fba858777c1b/molecules-25-05476-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be1e/7700379/9c808bb4c525/molecules-25-05476-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be1e/7700379/3e170b8e5b45/molecules-25-05476-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be1e/7700379/934fc582e2a5/molecules-25-05476-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be1e/7700379/a7708decfeca/molecules-25-05476-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be1e/7700379/d181dc57ef4c/molecules-25-05476-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be1e/7700379/0eab26b282bf/molecules-25-05476-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be1e/7700379/62ca08d1d065/molecules-25-05476-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be1e/7700379/3c2ce26879f3/molecules-25-05476-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be1e/7700379/f16b29ec6095/molecules-25-05476-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be1e/7700379/05f2c7d90d56/molecules-25-05476-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be1e/7700379/fba858777c1b/molecules-25-05476-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be1e/7700379/9c808bb4c525/molecules-25-05476-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be1e/7700379/3e170b8e5b45/molecules-25-05476-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be1e/7700379/934fc582e2a5/molecules-25-05476-g011.jpg

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