Neurobehavioral toxicity of methylmercury and PCBs Effects-profiles and sensitive populations.

A large and growing body of literature is available on the neurotoxicity of methylmercury and PCBs as expressed in the behavior of both humans and laboratory animals. Methylmercury and PCBs will be compared with PCBs with attention directed at overlaps and distinctions in their profiles of neurotoxicity. It is possible with methylmercury and, to a lesser extent, with PCBs to characterize the sensory, motor, and cognitive consequences of exposure. Methylmercury is emerging as a life-span developmental neurotoxicant: adverse effects of exposure have been identified in development and during aging in human populations as well as in laboratory animals. Less is known about the PCBs on this count. While the mechanisms of neurotoxicity are not understood for either class of compounds, emerging clues are pointing to the possibility of overlap in some mechanisms of neurotoxicity.