Department of Zoology, University of Rajasthan, Jaipur 302 004, India.
Environ Toxicol Pharmacol. 2003 Sep;14(3):91-8. doi: 10.1016/S1382-6689(03)00043-7.
Exposure of human population to pesticides and industrial pollutants has considerably increased the risk of human health hazard. In the present study, therefore we have sought to investigate the toxic effects of Methyl Parathion on male reproductive system of rat. The tested dose was given orally to the rats for 30 days at the dose level of 30 mg/kg/day. Sex organs weight analysis, histochemical and histopathological changes and mating trials were the criteria used to evaluate the reproductive efficacy of the treated rats. The body weight of the animals did not show any significant change. However, Methyl Parathion caused significant decrease in the weight of testis, epididymis, seminal vesicle and ventral prostate with marked pathomorphological changes. Also, marked reduction in epididymial and testicular sperm counts in exposed males were noticed. Fertility test showed 80% -ve fertility in treated animals. A significant reduction in the sialic acid contents of testis, epididymis, seminal vesicle, ventral prostate and testicular glycogen were noticed, while the protein and cholesterol content were raised significantly. From the above-mentioned findings, it has been concluded that exposure to Methyl Parathion has deleterious effects on male reproductive system of rat. Therefore, application of such insecticide should be limited to a designed program.
人群接触杀虫剂和工业污染物的程度大大增加了人类健康危害的风险。因此，在本研究中，我们试图研究甲基对硫磷对雄性大鼠生殖系统的毒性作用。以 30mg/kg/天的剂量水平，对大鼠进行了 30 天的口服给药测试。性器官重量分析、组织化学和组织病理学变化以及交配试验是评估治疗大鼠生殖功效的标准。动物体重没有明显变化。然而，甲基对硫磷导致睾丸、附睾、精囊和前列腺重量显著下降，并伴有明显的形态病理学变化。暴露组雄性动物的附睾和睾丸精子计数也明显减少。生育能力测试显示，处理组动物的生育能力为 80%阴性。还观察到睾丸、附睾、精囊、前列腺和睾丸糖原中的唾液酸含量显著降低，而蛋白质和胆固醇含量显著升高。从上述发现中可以得出结论，接触甲基对硫磷对雄性大鼠的生殖系统有有害影响。因此，应将此类杀虫剂的使用限制在设计的方案内。
