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Isolated GnRH deficiency: a disease model serving as a unique prism into the systems biology of the GnRH neuronal network.

作者信息

Balasubramanian Ravikumar, Crowley William F

机构信息

Harvard Reproductive Endocrine Sciences Center & The Reproductive Endocrine Unit of the Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.

出版信息

Mol Cell Endocrinol. 2011 Oct 22;346(1-2):4-12. doi: 10.1016/j.mce.2011.07.012. Epub 2011 Jul 12.

DOI:10.1016/j.mce.2011.07.012
PMID:21782888
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3226734/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7217/3226734/8f535c7a961c/nihms-322715-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7217/3226734/de57af53f4af/nihms-322715-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7217/3226734/736da741c1d2/nihms-322715-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7217/3226734/bb2caa414df6/nihms-322715-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7217/3226734/859a6d4195be/nihms-322715-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7217/3226734/8f535c7a961c/nihms-322715-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7217/3226734/de57af53f4af/nihms-322715-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7217/3226734/736da741c1d2/nihms-322715-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7217/3226734/bb2caa414df6/nihms-322715-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7217/3226734/859a6d4195be/nihms-322715-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7217/3226734/8f535c7a961c/nihms-322715-f0005.jpg

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The role of the prokineticin 2 pathway in human reproduction: evidence from the study of human and murine gene mutations.促动力素 2 途径在人类生殖中的作用：来自人类和鼠基因突变研究的证据。
Endocr Rev. 2011 Apr;32(2):225-46. doi: 10.1210/er.2010-0007. Epub 2010 Oct 29.
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Oligogenic basis of isolated gonadotropin-releasing hormone deficiency.孤立性促性腺激素释放激素缺乏症的寡基因基础。
Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15140-4. doi: 10.1073/pnas.1009622107. Epub 2010 Aug 9.
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TAC3/TACR3 mutations reveal preferential activation of gonadotropin-releasing hormone release by neurokinin B in neonatal life followed by reversal in adulthood.TAC3/TACR3 突变揭示了神经激肽 B 在新生儿期优先激活促性腺激素释放激素释放，随后在成年期逆转。
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