Department of Biochemistry, University of Oxford, Oxford, UK.
Semin Cell Dev Biol. 2011 Oct;22(8):906-12. doi: 10.1016/j.semcdb.2011.07.001. Epub 2011 Jul 18.
Recent data indicate an unexpected requirement for proteins that were hitherto considered to be dedicated to DNA repair to facilitate the faithful disjunction of sister chromatids in anaphase. These include the Bloom's syndrome gene product, BLM and its partners, as well as a number of proteins that are important for preventing Fanconi anemia (FA) in man. As part of an analysis of the roles of these proteins in mitosis, we identified a novel class of anaphase bridge structure, called an ultra-fine anaphase bridge (UFB). These UFBs are also defined by the presence of a SNF2 family protein called PICH. In this review, we will discuss the possible sources of UFBs, and how the BLM, PICH and FA proteins might serve to process these structures in order to maintain genome stability.
最近的数据表明，以前被认为专门用于 DNA 修复的蛋白质在后期姐妹染色单体的正确分离中需要一种意想不到的作用。这些蛋白质包括布卢姆综合征基因产物 BLM 及其伴侣，以及许多对预防人类范可尼贫血（FA）很重要的蛋白质。作为对这些蛋白质在有丝分裂中作用的分析的一部分，我们鉴定了一种新型的后期桥结构，称为超微后期桥（UFB）。这些 UFB 还被称为 PICH 的 SNF2 家族蛋白所定义。在这篇综述中，我们将讨论 UFB 的可能来源，以及 BLM、PICH 和 FA 蛋白如何作用于这些结构以维持基因组稳定性。
