Ivanova S F, Bures J
Institute of Physiology, Ukranian Academy of Sciences, Kiev, Union of Soviet Socialist Republics.
Behav Neurosci. 1990 Dec;104(6):948-54. doi: 10.1037//0735-7044.104.6.948.
Acquisition of conditioned taste aversion (CTA) is disrupted when 10 ng tetrodotoxin (TTX) is injected into both parabrachial nuclei of rats immediately after saccharin drinking and before LiCl poisoning (Ivanova & Bures, in press). Further analysis of this finding showed that parabrachial TTX injection (a) elicited retrograde amnesia also when applied 1, 2, or 4 days but not 8 days after CTA acquisition; (b) did not abolish CTA produced by 2 or 3 saccharin-LiCl pairings; (c) did not cause persistent increase of quinine threshold; and (d) elicited anterograde CTA amnesia when applied 1 but not 2, 4, or 8 days before CTA acquisition. TTX-induced amnesia is not due to persistent gustatory agnosia but rather to disruption of the protracted consolidation of the permanent CTA engram by prolonged cessation of impulse activity in the information storing network.
当在大鼠饮用糖精后且在注射氯化锂中毒之前立即向其双侧臂旁核注射10纳克河豚毒素（TTX）时，条件性味觉厌恶（CTA）的习得受到破坏（伊万诺娃和布雷什，即将发表）。对这一发现的进一步分析表明，向臂旁核注射TTX：（a）在CTA习得后1、2或4天而非8天应用时也会引发逆行性遗忘；（b）不会消除由2次或3次糖精 - 氯化锂配对产生的CTA；（c）不会导致奎宁阈值持续升高；（d）在CTA习得前1天而非2、4或8天应用时会引发顺行性CTA遗忘。TTX诱导的遗忘并非由于持续性味觉失认，而是由于信息存储网络中冲动活动长期停止，破坏了永久性CTA记忆痕迹的长期巩固。
