甲基汞增加大鼠脑脊液中 S100B 含量。
Methylmercury increases S100B content in rat cerebrospinal fluid.
机构信息
Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos, 2600 Anexo, CEP 90035 003, Porto Alegre, RS, Brazil; Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88040 900, Florianópolis, SC, Brazil.
出版信息
Environ Toxicol Pharmacol. 2005 Feb;19(2):249-53. doi: 10.1016/j.etap.2004.07.008.
S100B, a calcium binding protein physiologically produced and released by astrocytes, has been used as a peripheral marker of brain damage. Here, we investigated the effects of subcutaneous injections of methylmercury chloride (MeHg-5mg/kg), an environmental neurotoxicant, on S100B protein content in cerebrospinal fluid (CSF) of adult rats. In addition, the performance of animals in an open field (number of squares crossing and rearings) was also analyzed in order to obtain a possible link between alteration in S100B protein content in CSF and parameters related to neurological injury. MeHg treatment increased serum mercury and S100B protein levels in the CSF. A decrease in the numbers of crossings and rearings was observed in MeHg-treated animals when compared to control group, which suggests a possible neurological injury. The present data show, for the first time, increased S100B levels in CSF after exposure to a neurotoxic metal. Authors discuss the possibility of astrocytic involvement in MeHg-induced neurotoxicity.
S100B 是一种钙结合蛋白，在生理上由星形胶质细胞产生和释放，已被用作脑损伤的外周标志物。在这里，我们研究了皮下注射甲基汞氯化物（MeHg-5mg/kg），一种环境神经毒性物质，对成年大鼠脑脊液（CSF）中 S100B 蛋白含量的影响。此外，还分析了动物在开阔场中的表现（穿越和后肢站立的方格数），以获得 CSF 中 S100B 蛋白含量改变与神经损伤相关参数之间的可能联系。MeHg 处理增加了血清汞和 CSF 中的 S100B 蛋白水平。与对照组相比，MeHg 处理组的穿越和后肢站立次数减少，这表明可能存在神经损伤。目前的数据首次显示，暴露于神经毒性金属后，CSF 中的 S100B 水平升高。作者讨论了星形胶质细胞参与 MeHg 诱导的神经毒性的可能性。
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