辅酶 Q(10)和维生素 E 联合作用对镉诱导大鼠心脏抗氧化防御系统改变的影响。
Combined effects of coenzyme Q(10) and Vitamin E in cadmium induced alterations of antioxidant defense system in the rat heart.
机构信息
Institute of Biology and Ecology, Faculty of Science, University of Kragujevac, Radoja Domanovića 12, P.O. Box 60, 34000 Kragujevac, Serbia and Montenegro.
出版信息
Environ Toxicol Pharmacol. 2006 Sep;22(2):219-24. doi: 10.1016/j.etap.2006.03.008. Epub 2006 May 18.
Our study investigated the possible protective effects of coenzyme Q(10) (CoQ(10)) and Vitamin E (Vit E) alone or in combination against cadmium (Cd) induced alterations of antioxidant defense system in the rat heart. Male Wistar rats were injected with a single dose of CdCl(2) (0.4mg Cd/kg BW i.p.), CoQ(10) (20mg CoQ(10)/kg BW i.m.) and Vit E (20IU Vit E/kg BW i.m.), alone or in combination. Acute intoxication of rats with Cd were followed by significantly increased activity of antioxidant defense enzymes (CuZn SOD, GSH-Px, GST and GR), while the activity of Mn SOD was decreased in the heart. The treatment with Cd significantly decreased Vit C and Vit E concentrations. Treatment with CoQ(10) and Vit E reversed Cd-induced alterations of antioxidant defense system. The obtained results support the assumption that CoQ(10) and Vit E functions cooperatively with endogenous antioxidants and diminished toxic effects of Cd in rat heart.
本研究旨在探讨辅酶 Q(10)（CoQ(10)）和维生素 E（Vit E）单独或联合应用是否具有对抗镉（Cd）诱导的大鼠心脏抗氧化防御系统改变的保护作用。雄性 Wistar 大鼠一次性腹腔注射 CdCl(2)（0.4mg Cd/kg BW），肌肉注射 CoQ(10)（20mg CoQ(10)/kg BW）和 Vit E（20IU Vit E/kg BW），单独或联合应用。结果发现，大鼠急性 Cd 中毒后，抗氧化防御酶（CuZn SOD、GSH-Px、GST 和 GR）活性显著升高，而心脏中 Mn SOD 活性降低。Cd 处理还显著降低了 Vit C 和 Vit E 的浓度。CoQ(10)和 Vit E 的处理逆转了 Cd 诱导的抗氧化防御系统改变。这些结果支持了 CoQ(10)和 Vit E 与内源性抗氧化剂协同作用，并减轻了 Cd 在大鼠心脏中的毒性作用的假设。
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