Institute of Biology and Ecology, Faculty of Science, University of Kragujevac, Radoja Domanovića 12, P.O. Box 60, 34000 Kragujevac, Serbia and Montenegro.
Environ Toxicol Pharmacol. 2006 Sep;22(2):219-24. doi: 10.1016/j.etap.2006.03.008. Epub 2006 May 18.
Our study investigated the possible protective effects of coenzyme Q(10) (CoQ(10)) and Vitamin E (Vit E) alone or in combination against cadmium (Cd) induced alterations of antioxidant defense system in the rat heart. Male Wistar rats were injected with a single dose of CdCl(2) (0.4mg Cd/kg BW i.p.), CoQ(10) (20mg CoQ(10)/kg BW i.m.) and Vit E (20IU Vit E/kg BW i.m.), alone or in combination. Acute intoxication of rats with Cd were followed by significantly increased activity of antioxidant defense enzymes (CuZn SOD, GSH-Px, GST and GR), while the activity of Mn SOD was decreased in the heart. The treatment with Cd significantly decreased Vit C and Vit E concentrations. Treatment with CoQ(10) and Vit E reversed Cd-induced alterations of antioxidant defense system. The obtained results support the assumption that CoQ(10) and Vit E functions cooperatively with endogenous antioxidants and diminished toxic effects of Cd in rat heart.
本研究旨在探讨辅酶 Q(10)（CoQ(10)）和维生素 E（Vit E）单独或联合应用是否具有对抗镉（Cd）诱导的大鼠心脏抗氧化防御系统改变的保护作用。雄性 Wistar 大鼠一次性腹腔注射 CdCl(2)（0.4mg Cd/kg BW），肌肉注射 CoQ(10)（20mg CoQ(10)/kg BW）和 Vit E（20IU Vit E/kg BW），单独或联合应用。结果发现，大鼠急性 Cd 中毒后，抗氧化防御酶（CuZn SOD、GSH-Px、GST 和 GR）活性显著升高，而心脏中 Mn SOD 活性降低。Cd 处理还显著降低了 Vit C 和 Vit E 的浓度。CoQ(10)和 Vit E 的处理逆转了 Cd 诱导的抗氧化防御系统改变。这些结果支持了 CoQ(10)和 Vit E 与内源性抗氧化剂协同作用，并减轻了 Cd 在大鼠心脏中的毒性作用的假设。
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