Department of Cancer Chemoprevention, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Kolkata-700 026, West Bengal, India.
Environ Toxicol Pharmacol. 2006 Nov;22(3):298-308. doi: 10.1016/j.etap.2006.04.004. Epub 2006 May 2.
A series of organoselenocyanate compounds 4a-d were synthesized utilizing 1,8-naphthalic anhydride as the building unit. To evaluate the preventive potential of the Se compounds against Cd induced hepatic lipid peroxidation and oxidative stress, female Swiss Albino mice were exposed to Cd (as CdCl(2)) during 20 days at a dose of 1 or 2mg/kg bw given ip and the selenium compounds were given at the dose of 3mg/kg bw orally in a pretreatment and concomitant treatment schedule. Hepatic lipid peroxidation level was increased significantly by Cd, whereas the glutathione-S-transferase (GST), superoxide dismutase(SOD), reduced glutathione(GSH) and catalase(CAT) levels were decreased. The selenium compounds effectively decreased the hepatic lipid peroxidation level of the animals treated with Cd. The compounds were also effective in restoring the GST, SOD, and GSH as well as CAT level towards normal. Cadmium induced enhanced Serum alanine aminotransferase (ALT) and aspertate aminotransferase (AST) level were also decreased by the selenium compounds. The study evidences the preventive effects of organoselenocyanates 4a-d (Scheme 1) against Cd induced lipid peroxidation and oxidative stress, 4d showing the highest activity.
利用 1,8-萘二甲酸酐作为构建单元，合成了一系列有机硒氰酸酯化合物 4a-d。为了评估 Se 化合物对 Cd 诱导的肝脂质过氧化和氧化应激的预防潜力，雌性瑞士白化病小鼠在腹腔内给予剂量为 1 或 2mg/kg bw 的 Cd（作为 CdCl2）20 天，并在预处理和伴随治疗方案中以 3mg/kg bw 的剂量口服给予硒化合物。Cd 显著增加了肝脂质过氧化水平，而谷胱甘肽-S-转移酶（GST）、超氧化物歧化酶（SOD）、还原型谷胱甘肽（GSH）和过氧化氢酶（CAT）水平降低。硒化合物有效降低了 Cd 处理动物的肝脂质过氧化水平。这些化合物还能有效恢复 GST、SOD 和 GSH 以及 CAT 水平至正常。硒化合物还降低了 Cd 诱导的血清丙氨酸氨基转移酶（ALT）和天冬氨酸氨基转移酶（AST）水平升高。该研究证明了有机硒氰酸酯 4a-d（方案 1）对 Cd 诱导的脂质过氧化和氧化应激的预防作用，其中 4d 表现出最高的活性。
