The Institute for Neuroscience and Physiology, Department of Physiology/Endocrinology, the Sahlgrenska Academy at Göteborg University, Box 434, SE-405 30 Göteborg, Sweden.
Environ Toxicol Pharmacol. 2006 Nov;22(3):338-40. doi: 10.1016/j.etap.2006.05.002. Epub 2006 Jun 16.
We have investigated if propranolol, a non-selective β-blocker present in sewage effluents, affects heart rate in rainbow trout. During a 48h exposure to a very high concentration of propranolol (70.9μg/L) no effects on heart rate were found. After a subsequent intravenous injection of propranolol, heart rate remained unaffected in pre-exposed fish but was significantly lowered in naïve fish. Other studies have reported effects on the reproduction of fish by propranolol dissolved in water at much lower concentrations. The present study suggests that physiological systems under homeostatic control, like heart rate, may not be particularly sensitive despite being direct targets.
我们研究了是否存在于污水中的普萘洛尔（一种非选择性β受体阻滞剂）影响虹鳟鱼的心率。在暴露于非常高浓度的普萘洛尔（70.9μg/L）的 48 小时期间，未发现对心率有任何影响。在随后的静脉注射普萘洛尔后，预先暴露的鱼的心率保持不变，但在未暴露的鱼中则显著降低。其他研究报告了在低得多的浓度下溶于水的普萘洛尔对鱼类繁殖的影响。本研究表明，尽管是直接靶标，像心率这样的受体内稳态控制的生理系统可能不是特别敏感。
