他莫昔芬对日本青鳉（Oryzias latipes）早期生活阶段和生殖的影响。
Tamoxifen effects on the early life stages and reproduction of Japanese medaka (Oryzias latipes).
机构信息
State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, P.O. Box 2871, Shuangqing Road 18, Haidian District, Beijing 100085, PR China.
出版信息
Environ Toxicol Pharmacol. 2007 Jul;24(1):23-9. doi: 10.1016/j.etap.2007.01.003. Epub 2007 Jan 20.
Tamoxifen is widely used in the treatment of breast cancer and can enter the aquatic environment in municipal wastewater. To evaluate potential effects on embryonic development of Japanese medaka, fertilized eggs were exposed to tamoxifen at 1-625μg/l for 14 days. Adverse effects on hatchability and time to hatching only occurred at 125 and 625μg/l. Reproductive effects were assessed by exposing adults for 21 days to the same dose range. At all concentrations tested, tamoxifen significantly increased plasma vitellogenin levels in males in a dose-dependent manner. Fecundity and fertility were detrimentally affected at 625μg/l. Additionally, F1 eggs were removed from tamoxifen-contaminated water to evaluate transgenerational effects. Hatchability was affected at 625μg/l but no morphological deformities were observed. A significant dose-dependent increase in the proportion of genotypic males occurred at all concentrations greater than 5μg/l.
他莫昔芬被广泛用于乳腺癌的治疗，并且可以进入城市废水中的水生环境。为了评估其对日本青鳉胚胎发育的潜在影响，研究人员将受精卵暴露于 1-625μg/l 的他莫昔芬中 14 天。仅在 125 和 625μg/l 时，孵化率和孵化时间出现了不良影响。通过将成年鱼暴露于相同的剂量范围内 21 天来评估生殖毒性。在所有测试浓度下，他莫昔芬均以剂量依赖的方式显著增加了雄性鱼类的血浆卵黄蛋白原水平。在 625μg/l 时，生育力和繁殖力受到了损害。此外，将 F1 卵从受他莫昔芬污染的水中取出，以评估其跨代效应。在 625μg/l 时，孵化率受到了影响，但未观察到形态畸形。在所有大于 5μg/l 的浓度下，基因型雄性的比例均以剂量依赖的方式显著增加。
Zotero 插件