Environmental Science and Biotechnology Research Unit, Department of Zoology, Loyola College, Chennai 600034, Tamil Nadu, India.
Environ Toxicol Pharmacol. 2007 Nov;24(3):286-91. doi: 10.1016/j.etap.2007.07.001. Epub 2007 Jul 7.
The histopathology of lambda-cyhalothrin, a synthetic pyrethroid pesticide, on the gill, liver, intestine and kidney tissues in fish, mrigal (Cirrhinus mrigala), which is one of Indian major carp species were determined by light microscopy. The fish were experimentally exposed to sub-lethal concentrations (0.3ppb and 0.6ppb) of lambda-cyhalothrin for 10 days. Tissues were normal in the control group. Epithelial hyperplasia, aneurism, epithelial necrosis, desquamation, epithelial lifting, oedema, shortening of secondary lamellae and lamellar fusion were observed in gill tissues exposed to lambda-cyhalothrin. Necrosis of tubular epithelium, cloudy swelling of epithelial cells of renal tubules, narrowing of the tubular lumen, contraction of the glomerulus and expansion of space inside the Bowman's capsule were observed in the kidney tissues of fish after exposure. Hepatic lesions in fish exposed to lambda-cyhalothrin were characterized by hypertrophy of hepatocytes, cloudy degeneration, congestion, karyolysis, karyohexis, dilatation of sinusoids and focal necrosis. The intestinal lesions included infiltration of eosinophils into the lamina propria and atrophy of epithelial cells. The present study proves its toxic potential in terms of the damages induced by lambda-cyhalothrin in organ level. In natural condition lambda-cyhalothrin will be less than the present study, but continuous usage of the pesticide might lead to the concentration that was used in the experimental condition.
通过光镜观察了合成拟除虫菊酯杀虫剂 lambda-氯氰菊酯对鱼类（印度鲤鱼）鳃、肝、肠和肾组织的组织病理学影响。这些鱼被实验性地暴露于亚致死浓度（0.3ppb 和 0.6ppb）的 lambda-氯氰菊酯中 10 天。对照组的组织正常。暴露于 lambda-氯氰菊酯的鱼的鳃组织中观察到上皮细胞增生、动脉瘤、上皮坏死、脱落、上皮抬起、水肿、次级鳃片缩短和鳃片融合。暴露后鱼的肾脏组织中观察到肾小管上皮细胞坏死、肾小管上皮细胞浑浊肿胀、管腔变窄、肾小球收缩和鲍曼氏囊内空间扩张。暴露于 lambda-氯氰菊酯的鱼的肝损伤特征为肝细胞肥大、浑浊变性、充血、核溶解、核碎裂、窦扩张和局灶性坏死。肠的病变包括固有层嗜酸性粒细胞浸润和上皮细胞萎缩。本研究从器官水平上证明了 lambda-氯氰菊酯引起的损伤具有其毒性潜力。在自然条件下，lambda-氯氰菊酯的浓度将低于本研究，但该农药的持续使用可能会导致实验条件下使用的浓度。
