Padilha Roberto Queiroz, Riera Rachel, Átallah Alvaro Nagib
Department of Medicine at the Federal University of São Carlos, São Paulo, Brazil.
Homeopathy. 2011 Jul;100(3):116-21. doi: 10.1016/j.homp.2010.11.007.
Poisoning due to lead and its compounds has short and long-term effects primarily on the nervous, hematopoietic, gastrointestinal, cardiovascular, musculoskeletal, renal and reproductive systems. It can manifest in acute or chronic symptoms. Measuring serum concentration is the primary method for diagnosing and monitoring exposed workers. Presently, elevated lead levels are treated by drugs whose effectiveness is contested on various fronts. Experimental studies suggest that homeopathic preparations may be in controlling blood lead levels in laboratory animals, creating the need for controlled studies to evaluate the effectiveness and safety of these preparations in humans.
To evaluate the effectiveness of the homeopathic preparation Plumbum metallicum in reducing the blood lead level of workers exposed to this metal.
Double-blind randomized trial.
Workers' clinic in the Ajax battery plant, which employs 900 workers with varying degrees of lead exposure in Bauru, São Paulo State, Brazil.
131 workers exposed to lead.
Plumbum metallicum 15 cH or placebo, orally for 35 days.
The percentage of workers who demonstrated a reduction in lead counts by a percentage greater than or equal to 25% following treatment was the same for both groups: 20.3% in the homeopathic groups versus 21% in the control group [Relative Risk (RR) = 0.95, confidential interval (CI) 95%: 0.47-1.92)]. Analysis by intention-to-treat also did not show any difference between the groups: 18.2% in the treated group versus 20% in the placebo group (RR = 0.91, CI 95%: 0.45-1.84).
The homeopathic preparation Plumbum metallicum had no effect, in this study, in terms of reducing serum lead in workers exposed to lead.
铅及其化合物中毒主要对神经、造血、胃肠、心血管、肌肉骨骼、肾脏和生殖系统产生短期和长期影响。其症状可表现为急性或慢性。测量血清浓度是诊断和监测接触铅的工人的主要方法。目前，铅水平升高的治疗采用的药物在各方面的有效性都存在争议。实验研究表明，顺势疗法制剂可能有助于控制实验动物的血铅水平，因此需要进行对照研究来评估这些制剂对人类的有效性和安全性。
评估顺势疗法制剂金属铅对降低接触该金属的工人血铅水平的有效性。
双盲随机试验。
位于巴西圣保罗州包鲁市的阿贾克斯电池厂的工人诊所，该厂雇佣了900名不同程度接触铅的工人。
131名接触铅的工人。
口服15cH的金属铅或安慰剂，持续35天。
治疗后血铅计数降低百分比大于或等于25%的工人百分比在两组中相同：顺势疗法组为20.3%，对照组为21%[相对危险度（RR）=0.95，95%置信区间（CI）：0.47 - 1.92]。意向性分析也未显示两组之间有任何差异：治疗组为18.2%，安慰剂组为20%（RR = 0.91，95%CI：0.45 - 1.84）。
在本研究中，顺势疗法制剂金属铅在降低接触铅工人的血清铅方面没有效果。
