Department of Community Medicine, School of Public Health, University of Hong Kong, China.
Ann Epidemiol. 2011 Nov;21(11):857-63. doi: 10.1016/j.annepidem.2011.06.002. Epub 2011 Jul 23.
To examine, via cross-sectional analysis, the dose-response association between physical activity and cognitive function in Chinese subjects.
A total of 27,651 participants aged 50 to 85 years were recruited from 2003 to 2008. Information on potential confounders, including demographic and anthropometric characteristics, socioeconomic position, lifestyle, and disease history, was collected by standardized interview and procedures. Cognitive function was assessed by the delayed 10-word recall test (DWRT).
When the International Physical Activity Questionnaire was used, we found that most of the participants were classified as physically active (53.1%), with 42.4% moderately active and 4.5% physically inactive. Significant dose-response relations across quintiles of metabolic equivalent value (METs) with DWRT score in participants with or without good self-rated health were found (all p for trend <.001). In participants with poor self-rated heath, compared with the first quintile of METs, those in the fifth quintile (highest METs) had a significantly reduced risk for mild cognitive impairment by 28% (adjusted odds ratio, 0.72; 95% confidence interval, 0.58-0.89, p < .01; p for trend = .006). After additional adjustment for depression, we found that the association between physical activity and DWRT score remained significant.
A significant dose-response relationship between physical activity and cognitive function was found, and the association was more pronounced in participants with poor self-rated health.
通过横断面分析，研究中国人群中体力活动与认知功能之间的剂量-反应关系。
共招募了 2003 年至 2008 年间年龄在 50 至 85 岁的 27651 名参与者。通过标准化访谈和程序收集了潜在混杂因素的信息，包括人口统计学和人体测量特征、社会经济地位、生活方式和疾病史。认知功能通过延迟 10 字回忆测试（DWRT）进行评估。
当使用国际体力活动问卷时，我们发现大多数参与者被归类为体力活动活跃（53.1%），其中 42.4%为中度活跃，4.5%为不活跃。在自我报告健康状况良好或不佳的参与者中，均发现代谢当量值（METs）五分位数与 DWRT 评分之间存在显著的剂量-反应关系（所有趋势检验 p 值<.001）。在自我报告健康状况不佳的参与者中，与第一五分位数的 METs 相比，第五五分位数（最高 METs）的轻度认知障碍风险显著降低了 28%（调整后的优势比，0.72；95%置信区间，0.58-0.89，p<.01；趋势检验 p 值<.006）。在进一步调整抑郁后，我们发现体力活动与 DWRT 评分之间的关联仍然显著。
发现体力活动与认知功能之间存在显著的剂量-反应关系，且该关联在自我报告健康状况不佳的参与者中更为明显。
