P. G. Department of Studies in Chemistry, Karnatak University, Dharwad 580 003, India.
Bioelectrochemistry. 2012 Feb;83:1-7. doi: 10.1016/j.bioelechem.2011.06.008. Epub 2011 Jul 5.
The electrochemical oxidation of a hemorheologic drug, pentoxifylline was investigated at a multi-walled carbon nanotubes-paraffin oil paste electrode using cyclic and differential pulse voltammetry. The oxidation process was irreversible over the pH range studied and exhibited an adsorption-controlled behavior. All experimental parameters have been optimized. Under the optimum conditions, the oxidation peak current was linearly proportional to the concentration of pentoxifylline in the range of 3.0 × 10(-5) to 2.0 × 10(-4)M with a detection limit of 1.69 × 10(-7)M by differential pulse voltammetry with 180s accumulation. The proposed method was successfully applied to pentoxifylline determination in pharmaceutical and urine samples. Satisfactory recoveries of the analyte from the real samples and a good agreement between the concentration ranges studied and the real ranges encountered in the urine samples, when treated with the drug make the developed method applicable in clinical analysis. This method can also be employed in quality control and routine determination of drugs in pharmaceutical formulations.
采用循环伏安法和差分脉冲伏安法研究了血液流变学药物己酮可可碱在多壁碳纳米管-石蜡油糊电极上的电化学氧化。在研究的 pH 范围内，氧化过程是不可逆的，表现出吸附控制行为。优化了所有实验参数。在最佳条件下，差分脉冲伏安法在 3.0×10(-5)至 2.0×10(-4)M 浓度范围内，氧化峰电流与己酮可可碱浓度呈线性关系，检测限为 1.69×10(-7)M，通过 180s 累积。该方法成功应用于药物和尿液样品中己酮可可碱的测定。从实际样品中分析物的回收率令人满意，并且在药物处理后的尿液样品中研究的浓度范围与实际浓度范围之间存在良好的一致性，使所开发的方法适用于临床分析。该方法还可用于药物制剂的质量控制和常规药物测定。
