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What if gut hormones aren't really hormones: DPP-4 inhibition and local action of GLP-1 in the gastrointestinal tract.

作者信息

D'Alessio David A

机构信息

Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, ML 0547, University of Cincinnati, Cincinnati Ohio 45267-0547, USA.

出版信息

Endocrinology. 2011 Aug;152(8):2925-6. doi: 10.1210/en.2011-1385.

DOI:10.1210/en.2011-1385
PMID:21785013
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3138230/
Abstract
摘要

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本文引用的文献

1
Physiological and pharmacological mechanisms through which the DPP-4 inhibitor sitagliptin regulates glycemia in mice.通过二肽基肽酶-4 抑制剂西他列汀调控小鼠血糖的生理和药理机制。
Endocrinology. 2011 Aug;152(8):3018-29. doi: 10.1210/en.2011-0286. Epub 2011 Jun 14.
2
Genetic tracing of Nav1.8-expressing vagal afferents in the mouse.在小鼠中对表达 Nav1.8 的迷走传入神经进行遗传示踪。
J Comp Neurol. 2011 Oct 15;519(15):3085-101. doi: 10.1002/cne.22667.
3
The effect of DPP-4 inhibition with sitagliptin on incretin secretion and on fasting and postprandial glucose turnover in subjects with impaired fasting glucose.西他列汀对空腹血糖受损患者肠促胰岛素分泌及空腹和餐后葡萄糖代谢的影响。
Clin Endocrinol (Oxf). 2010 Aug;73(2):189-96. doi: 10.1111/j.1365-2265.2009.03764.x. Epub 2009 Dec 18.
4
Incretin-based therapies for type 2 diabetes mellitus.用于2型糖尿病的基于肠促胰岛素的疗法。
Nat Rev Endocrinol. 2009 May;5(5):262-9. doi: 10.1038/nrendo.2009.48.
5
Fasting and postprandial concentrations of GLP-1 in intestinal lymph and portal plasma: evidence for selective release of GLP-1 in the lymph system.肠道淋巴液和门静脉血浆中胰高血糖素样肽-1（GLP-1）的空腹及餐后浓度：GLP-1在淋巴系统中选择性释放的证据
Am J Physiol Regul Integr Comp Physiol. 2007 Dec;293(6):R2163-9. doi: 10.1152/ajpregu.00911.2006. Epub 2007 Sep 26.
6
Efficacy and safety of incretin therapy in type 2 diabetes: systematic review and meta-analysis.肠促胰岛素疗法治疗2型糖尿病的疗效与安全性：系统评价与荟萃分析
JAMA. 2007 Jul 11;298(2):194-206. doi: 10.1001/jama.298.2.194.
7
Glucagon-like peptide-1 (GLP-1) receptors expressed on nerve terminals in the portal vein mediate the effects of endogenous GLP-1 on glucose tolerance in rats.门静脉神经末梢上表达的胰高血糖素样肽-1（GLP-1）受体介导内源性GLP-1对大鼠葡萄糖耐量的影响。
Endocrinology. 2007 Oct;148(10):4965-73. doi: 10.1210/en.2006-0153. Epub 2007 Jun 21.
8
Biology of incretins: GLP-1 and GIP.肠促胰岛素的生物学：胰高血糖素样肽-1和葡萄糖依赖性促胰岛素多肽
Gastroenterology. 2007 May;132(6):2131-57. doi: 10.1053/j.gastro.2007.03.054.
9
Synergistic effect of portal glucose and glucagon-like peptide-1 to lower systemic glucose and stimulate counter-regulatory hormones.门静脉葡萄糖与胰高血糖素样肽-1协同降低全身血糖并刺激反调节激素。
Diabetologia. 2005 May;48(5):967-75. doi: 10.1007/s00125-005-1709-3. Epub 2005 Apr 14.
10
Glucagon-like peptide-1 mediates the therapeutic actions of DPP-IV inhibitors.胰高血糖素样肽-1介导二肽基肽酶-4抑制剂的治疗作用。
Diabetologia. 2005 Apr;48(4):612-5. doi: 10.1007/s00125-005-1705-7. Epub 2005 Mar 10.