Yousem S A, Ray L, Paradis I L, Dauber J A, Griffith B P
Department of Pathology, Presbyterian University Hospital, Pittsburgh, Pennsylvania 15213.
Ann Thorac Surg. 1990 Mar;49(3):424-8. doi: 10.1016/0003-4975(90)90248-5.
Dendritic cells are essential for the activation of the type IV immunological reactions that are intrinsic to rejection of transplanted organs. We evaluated the number of dendritic cells in the recipient and donor portions of the trachea and donor bronchi of 6 heart-lung transplant recipients, 3 of whom had evidence of bronchiolitis obliterans, a presumed manifestation of chronic rejection of the lung. As compared with recipients without bronchiolitis obliterans, patients with it showed a significant increase in the number of S100-protein-positive dendritic cells in the tracheal and bronchial epithelium and submucosa of the donor organs. This finding of increased accessory cells in the transplanted mucosa provides support for the belief that bronchiolitis obliterans is an immunologically mediated form of chronic rejection.
树突状细胞对于激活IV型免疫反应至关重要，而这种免疫反应是移植器官排斥反应所固有的。我们评估了6例心肺移植受者气管的受体和供体部分以及供体支气管中树突状细胞的数量，其中3例有闭塞性细支气管炎的证据，这被认为是肺慢性排斥反应的一种表现。与没有闭塞性细支气管炎的受者相比，患有该病的患者在供体器官的气管和支气管上皮及黏膜下层中，S100蛋白阳性树突状细胞的数量显著增加。移植黏膜中辅助细胞增加这一发现支持了以下观点，即闭塞性细支气管炎是一种免疫介导的慢性排斥反应形式。
