DIB/TBHP 体系中未活化亚甲基 C-H 的氧化反应。

An unexpected oxidation of unactivated methylene C-H using DIB/TBHP protocol.

机构信息

Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.

出版信息

Org Lett. 2011 Aug 19;13(16):4308-11. doi: 10.1021/ol2016466. Epub 2011 Jul 25.

DOI:10.1021/ol2016466

Abstract

An in situ generated hypervalent iodine species, bis(tert-butylperoxy)iodobenzene, was used as a peroxy radical source for the oxidation of unreactive, remote, and isolated alkyl (cyclic or aliphatic) esters and amides to the corresponding keto compounds under very mild conditions.

摘要

原位生成的高价碘物种，双（叔丁基过氧基）碘苯，被用作过氧自由基源，用于在非常温和的条件下将惰性、远程和孤立的烷基（环状或脂肪族）酯和酰胺氧化为相应的酮化合物。