Medical Education Unit, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Pharmacogenomics. 2011 Jul;12(7):1051-9. doi: 10.2217/pgs.11.42.
Despite the fast-growing literature and the emerging support from regulatory drug agencies, the translation of pharmacogenetics (PGx) into the clinic is still rather limited; it seems that many existing challenges are yet to be overcome prior to an extensive adoption of PGx-based diagnostics. This article describes the results of an explorative nonrepresentative survey that attempted to evaluate the perceived status quo of, and the obstacles facing, PGx implementation in clinical practice in countries with emerging and developing economies versus countries with advanced economies. This study is a useful starting point to help gain better insight into the international, rather than merely the regional, barriers facing the lag in PGx implementation in the clinic. A more transparent picture about these priorities can be constructed through conducting a similar study on a more representative sample of respondents/participants.
尽管相关文献快速增长,监管药物机构也开始提供支持,但药物遗传学(PGx)向临床的转化仍然相当有限;在广泛采用基于 PGx 的诊断之前,似乎还有许多现有挑战需要克服。本文描述了一项探索性非代表性调查的结果,该调查试图评估新兴和发展中经济体与发达经济体的临床实践中 PGx 实施的现状和面临的障碍。这项研究是一个有用的起点,可以帮助更好地了解国际上而非仅仅是区域内 PGx 在临床实施中滞后的障碍。通过对更多具有代表性的受访者/参与者进行类似的研究,可以构建出关于这些优先事项的更清晰的图景。