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黎巴嫩的药物基因组学:现状、挑战与机遇

Pharmacogenomics in Lebanon: current status, challenges and opportunities.

作者信息

Chidiac Lorenzo, Yazbeck Hady, Mahfouz Rami, Zgheib Nathalie K

机构信息

Faculty of Medicine, American University of Beirut, Beirut, Lebanon.

Department of Pathology and Laboratory Medicine, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.

出版信息

Pharmacogenomics J. 2024 May 22;24(3):16. doi: 10.1038/s41397-024-00336-z.

Abstract

Pharmacogenomics (PGx) research and applications are of utmost relevance in Lebanon considering its population genetic diversity. Moreover, as a country with regional leadership in medicine and higher education, Lebanon holds a strong potential in contributing to PGx research and clinical implementation. In this manuscript, we first review and evaluate the available PGx research conducted in Lebanon, then describe the current status of PGx practice in Lebanon while reflecting on the local and regional challenges, and highlighting areas for action, and opportunities to move forward. We specifically expand on the status of PGx at the American University of Beirut Faculty of Medicine and Medical Center as a case study and guide for the further development of local and regional comprehensive PGx research, teaching, and clinical implementation programs. We also delve into the status of PGx knowledge and education, and prospects for further advancement such as with online courses and certificates.

摘要

考虑到黎巴嫩的人群基因多样性,药物基因组学(PGx)研究及应用在该国极为重要。此外,作为在医学和高等教育领域具有地区领导地位的国家,黎巴嫩在推动PGx研究及临床应用方面拥有巨大潜力。在本论文中,我们首先回顾并评估黎巴嫩已开展的PGx研究,接着描述黎巴嫩PGx实践的现状,同时思考当地和地区面临的挑战,突出行动领域以及未来发展的机遇。我们特别详细阐述了贝鲁特美国大学医学院及医疗中心的PGx状况,将其作为当地和地区全面PGx研究、教学及临床应用项目进一步发展的案例研究和指南。我们还深入探讨了PGx知识与教育的现状,以及诸如在线课程和证书等进一步发展的前景。

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