Department of Dermatology, University Hospital, School of Medicine, Malaga, Spain.
J Dermatolog Treat. 2012 Dec;23(6):428-30. doi: 10.3109/09546634.2011.590789. Epub 2011 Jul 25.
Surgical excision is the preferred method of eradicating Bowen´s disease (BD). Photodynamic therapy (PDT) has been successfully used for treatment of actinic keratosis, basal cell carcinoma, and BD.
Our aim was to evaluate the efficacy and tolerability of PDT for treatment of extensive BD.
Eighteen patients with 23 biopsy-proven BD lesions were treated with PDT. We defined as extensive those lesions large than 3 cm. Methyl aminolevulinate cream was applied for 3 h before illumination with an light emitting diode light source at a wavelength of 630 nm (energy density of 37 J/cm²). Treatment was repeated 1 week later.
After 12 weeks of treatment, 22 of 23 BD lesions (90%) showed complete clinical response. Only three lesions recurred after a follow-up period of 12 months. Cosmetic outcome at 12 months was good or excellent in 94% of patients.
Methyl aminolevulinate PDT is an effective treatment option for extensive BD with excellent cosmesis.
手术切除是根除 Bowen 病（BD）的首选方法。光动力疗法（PDT）已成功用于治疗光化性角化病、基底细胞癌和 BD。
我们旨在评估 PDT 治疗广泛 BD 的疗效和耐受性。
18 名经活检证实的 23 处 BD 病变患者接受 PDT 治疗。我们将病变面积大于 3cm 的定义为广泛病变。在光照前 3 小时涂抹甲基氨基酮戊酸乳膏，使用 630nm 发光二极管光源（能量密度 37J/cm²）进行光照。1 周后重复治疗。
治疗 12 周后，23 处 BD 病变中有 22 处（90%）完全临床缓解。随访 12 个月后，仅 3 处病变复发。12 个月时，94%的患者美容效果良好或优秀。
对于广泛的 BD，甲氨基酮戊酸 PDT 是一种有效的治疗选择，具有良好的美容效果。
