Palaniappan Vijayasankar, Karthikeyan Kaliaperumal
Department of Dermatology, Venereology and Leprosy, Sri ManakulaVinayagar Medical College and Hospital, Puducherry, India.
Indian Dermatol Online J. 2022 Mar 3;13(2):177-189. doi: 10.4103/idoj.idoj_257_21. eCollection 2022 Mar-Apr.
Bowen's disease (BD) is an in-situ squamous cell carcinoma of epidermis. The etiology of BD is multifactorial with high incidence among Caucasians. BD is common in photo-exposed areas of skin, but other sites can also be involved. Lesions are usually solitary. The morphology of BD differs based on age of the lesion, site of origin, and the degree of keratinization. BD is considered as the "lull before the storm," which precedes an overt squamous cell carcinoma. Histopathology is the gold standard diagnostic modality to confirm the diagnosis. Immunohistochemistry, dermoscopy, and reflectance confocal microscopy are the adjuvant modalities used in the diagnosis of BD. The treatment depends on various factors like site, size, immune status, patient's age, esthetic outcome, etc. The available therapeutic modalities include topical chemotherapy, surgical modalities, light-based modalities, and destructive therapies. It requires a combined effort of dermatologist, oncosurgeon, and plastic surgeon to plan and execute the management in various presentations of BD.
鲍温病（BD）是一种表皮原位鳞状细胞癌。BD的病因是多因素的，在白种人中发病率较高。BD在皮肤的光照暴露部位常见，但其他部位也可受累。皮损通常为单发。BD的形态因皮损年龄、起源部位和角化程度而异。BD被认为是明显鳞状细胞癌之前的“暴风雨前的平静”。组织病理学是确诊的金标准诊断方法。免疫组织化学、皮肤镜检查和反射式共聚焦显微镜检查是用于BD诊断的辅助方法。治疗取决于部位、大小、免疫状态、患者年龄、美学效果等多种因素。现有的治疗方法包括局部化疗、手术方法、光疗法和破坏性疗法。需要皮肤科医生、肿瘤外科医生和整形外科医生共同努力，以规划和实施BD各种表现形式的管理。
