Department of Pharmacology, C.L. Baid Metha College of Pharmacy and Research Foundation, Tamilnadu, India.
Drug Chem Toxicol. 2012 Jan;35(1):104-15. doi: 10.3109/01480545.2011.589442. Epub 2011 Sep 22.
Manasamitra vatakam (MMV) has long been used as a traditional medicine in India for the treatment of psychosomatic diseases, anxiety neurosis, and stress. The present study was designed to examine the neuroprotective effect of MMV against aluminum (Al)-induced memory impairment and oxidative damage in rats. Neurotoxicity was induced by the administration of Al [100 mg/kg body weight (b.w.) per oral (p.o.)/day] to Wistar albino rats for 90 days. Al administration induced neurotoxicity as well as oxidative stress by affecting the active avoidance and memory impairment, as well as altering antioxidants, such as HSP70 protein, superoxide dismutase, catalase, reduced glutathione, glutathione peroxidase, and acetylcholinesterase. It was observed that the administration of MMV (100 mg/kg b.w./p.o./day) along with AlCl(3) improves memory performance and antioxidant activity against Al-induced neurotoxicity in rats. In conclusion, these data suggest that MMV can prevent brain damage from Al-induced neurotoxicity in rats and thus can be used as a neuroprotective agent.
曼纳萨米特拉瓦塔卡姆（MMV）长期以来一直被印度用作传统药物，用于治疗身心疾病、焦虑症和压力。本研究旨在研究 MMV 对铝（Al）诱导的大鼠记忆障碍和氧化损伤的神经保护作用。通过给 Wistar 白化大鼠口服（p.o.）每天 100mg/kg 体重（b.w.）的 Al 90 天来诱导神经毒性。Al 的给药通过影响主动回避和记忆障碍以及改变 HSP70 蛋白、超氧化物歧化酶、过氧化氢酶、还原型谷胱甘肽、谷胱甘肽过氧化物酶和乙酰胆碱酯酶等抗氧化剂来诱导神经毒性和氧化应激。结果表明，MMV（100mg/kg b.w./p.o./天）与 AlCl3 联合给药可改善记忆性能并提高抗氧化活性，从而对抗 Al 诱导的大鼠神经毒性。总之，这些数据表明 MMV 可预防大鼠铝诱导的神经毒性引起的脑损伤，因此可用作神经保护剂。
