Institut für Medizinische Mikrobiologie und Hygiene, Universitätsklinikum Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany.
Biochem Soc Trans. 2011 Aug;39(4):1045-50. doi: 10.1042/BST0391045.
The human BPI (bactericidal/permeability-increasing protein), stored in primary azurophilic granula of neutrophil granulocytes and produced by mucosal epithelia, has been known for decades to bind LPS (lipopolysaccharide) with very high affinity and to efficiently kill Gram-negative bacteria. Thus BPI potentially represents a central component of the innate immune system to directly combat microbes and modulate subsequent adaptive immune responses. Especially in the lungs, which are frequently exposed to a variety of inhaled pathogens, antimicrobial innate defence molecules such as BPI, are of exceptional relevance. In the present review, we highlight possible functions of BPI during acute pneumonia and CF (cystic fibrosis)-associated chronic infections in the lung.
人类 BPI（杀菌/通透性增加蛋白）储存在中性粒细胞的初级嗜苯胺蓝颗粒中，并由黏膜上皮产生，几十年来，它一直被认为能够与 LPS（脂多糖）高亲和力结合，并有效地杀死革兰氏阴性菌。因此，BPI 可能是先天免疫系统的核心组成部分，能够直接对抗微生物并调节随后的适应性免疫反应。特别是在肺部，肺部经常暴露于各种吸入性病原体中，抗菌先天防御分子如 BPI 具有特殊的重要性。在本综述中，我们强调了 BPI 在急性肺炎和 CF（囊性纤维化）相关慢性肺部感染中的可能作用。
