Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.
Biochem Soc Trans. 2011 Aug;39(4):994-9. doi: 10.1042/BST0390994.
BPI (bactericidal/permeability-increasing protein) is a 55 kDa anti-infective molecule expressed in neutrophil and eosinophil granules and on some epithelial cells. BPI's high affinity for the lipid A region of endotoxin targets its opsonizing, microbicidal and endotoxin-neutralizing activities towards Gram-negative bacteria. Several immunocompromised patient populations demonstrate BPI deficiency, including newborns, those with anti-neutrophil cytoplasmic antibodies (as in cystic fibrosis and HIV infection) and those exposed to radiochemotherapy. BPI may be replenished by administering agents that induce its expression or by administration of recombinant BPI congeners, potentially shielding BPI-deficient individuals against Gram-negative bacterial infection, endotoxemia and its toxic sequelae.
杀菌/通透性增加蛋白（BPI）是一种 55kDa 的抗感染分子，存在于中性粒细胞和嗜酸性粒细胞颗粒中和某些上皮细胞表面。BPI 对内毒素脂质 A 区域具有高亲和力，使其调理、杀菌和中和内毒素的活性针对革兰氏阴性菌。一些免疫功能低下的患者群体表现出 BPI 缺乏，包括新生儿、抗中性粒细胞胞质抗体阳性（如囊性纤维化和 HIV 感染）和接受放化疗的患者。通过给予诱导其表达的药物或给予重组 BPI 同系物，BPI 可能会得到补充，从而使 BPI 缺乏的个体免受革兰氏阴性细菌感染、内毒素血症及其毒性后果的影响。
