Environmental Biochemistry lab, Department of Biochemistry, University College of Medical Sciences & GTB Hospital, University of Delhi, Dilshad Garden, Delhi 110095, India.
Environ Toxicol Pharmacol. 2010 Mar;29(2):126-30. doi: 10.1016/j.etap.2009.12.001. Epub 2009 Dec 16.
Cytochrome P450 (CYP) 1A1 and CYP3A4 are important phase I xenobiotic metabolizing enzymes involved in the metabolism of numbers of toxins, endogenous hormones and pharmaceutical drugs. Polymorphisms in these phase I genes can alter enzyme activity and are known to be associated with cancer susceptibility related to environmental toxins and hormone exposure. Their genotypes may also display ethnicity dependent population frequencies. The present study was aimed to determine the frequencies of commonly known functional polymorphisms of CYP1A1 and CYP3A4 in North Indian population. Allelic frequency of CYP1A1 polymorphisms, m1, m2 and m4 were observed to be 40.3, 31.2 and 0% respectively. Frequency of CYP3A4*1B polymorphism was 0%. We observed inter as well as intra ethnic variation in the distribution of frequency of these polymorphisms. Analysis of polymorphisms in these genes might help in predicting the risk of cancer. Our results emphasize the need for more such studies in "high risk populations".
细胞色素 P450（CYP）1A1 和 CYP3A4 是重要的 I 相异源生物代谢酶，参与许多毒素、内源性激素和药物的代谢。这些 I 相基因的多态性可以改变酶活性，并且已知与环境毒素和激素暴露相关的癌症易感性有关。它们的基因型也可能显示出与种族有关的人群频率。本研究旨在确定北印度人群中常见的 CYP1A1 和 CYP3A4 功能多态性的频率。CYP1A1 多态性 m1、m2 和 m4 的等位基因频率分别为 40.3%、31.2%和 0%。CYP3A4*1B 多态性的频率为 0%。我们观察到这些多态性在分布频率上存在种间和种内变异。对这些基因多态性的分析可能有助于预测癌症的风险。我们的结果强调了在“高危人群”中进行更多此类研究的必要性。
