Department of Internal Medicine, Occupational Diseases and Hypertension, Wroclaw Medical University, Pasteur 4, PL 50-367 Wroclaw, Poland.
Environ Toxicol Pharmacol. 2011 Mar;31(2):267-77. doi: 10.1016/j.etap.2010.12.002. Epub 2010 Dec 17.
We have evaluated current knowledge on relations between environmental and occupational exposure to lead with a strong emphasis on cardiovascular disease risk factors, such as the influence of lead compounds on lipid disturbances and arterial blood pressure. In addition, "novel" biochemical and vascular risk factors for cardiovascular diseases were discussed, as well as the combination of lead exposure and genetic predisposition to cardiovascular diseases. Occupationally and educationally, awareness of the unfavourable effects of lead on cardiovascular diseases risk factors should be emphasised. Indeed, accurate identification of the various mechanisms that might account for the effects of lead on the cardiovascular system should be of the highest priority in this field of research.
我们评估了目前关于环境和职业暴露于铅之间关系的知识，重点强调了心血管疾病风险因素，如铅化合物对脂质紊乱和动脉血压的影响。此外，还讨论了心血管疾病的“新”生化和血管风险因素，以及铅暴露和心血管疾病遗传易感性的结合。在职业和教育方面，应该强调铅对心血管疾病风险因素的不利影响的认识。实际上，准确识别可能导致铅对心血管系统产生影响的各种机制应该是该研究领域的重中之重。
