Janson M, Janson I, Lydtin H
Dtsch Zahnarztl Z. 1977 Nov;32(11):898-902.
A double blind trial was undertaken to determine whether the addition of the beta-receptor blocker Betadrenol in two different doses to a lidocaine solution containing adrenaline could influence the exogenous and endogenous beta-adrenergic effects in the field of dental interventions under local anesthesia. It could be shown that already very small amounts of the beta-receptor blocker Betadrenol could suspend beta-adrenergic stimulation of the heart and so prevent unwanted circulatory reactions without side effects on the central nervous system.
进行了一项双盲试验,以确定在含有肾上腺素的利多卡因溶液中添加两种不同剂量的β受体阻滞剂倍他洛尔是否会影响局部麻醉下牙科干预领域的外源性和内源性β肾上腺素能效应。结果表明,极少量的β受体阻滞剂倍他洛尔就能抑制心脏的β肾上腺素能刺激,从而预防不必要的循环反应,且对中枢神经系统无副作用。