儿茶酚-O-甲基转移酶变体与度洛西汀治疗抑郁症反应的相关性。
Association of catechol-O-methyltransferase variants with duloxetine response in major depressive disorder.
机构信息
Neuroscience Department, Eli Lilly and Company, LLC, Indianapolis, IN, USA.
出版信息
Psychiatry Res. 2011 Oct 30;189(3):475-7. doi: 10.1016/j.psychres.2011.07.002. Epub 2011 Jul 24.
Single-nucleotide and diplotype associations with 17-item Hamilton Depression Rating Scale (HAMD(17)) total score changes were examined, based on catechol-O-methyltransferase (COMT) rs165599 status in duloxetine-treated, self-identified white patients with major depressive disorder. COMT rs165737 and a diplotype containing COMT rs165599 and COMT rs165737 were associated with HAMD(17) total score changes.
根据接受度洛西汀治疗的、自我报告为患有重度抑郁症的白种患者的儿茶酚-O-甲基转移酶（COMT）rs165599 状态，研究了单核苷酸和二联体型与 17 项汉密尔顿抑郁评定量表（HAMD(17)）总分变化的关联。COMT rs165737 和包含 COMT rs165599 和 COMT rs165737 的二联型与 HAMD(17)总分变化相关。
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