Pechadre J C, Maupetit F, Maupetit J, Gathier M C, Brun J P, Gibert J
Encephale. 1977;3(3):241-9.
The effect of clonazepam, taken per-os and in very progressive doses, has been studied by the authors on fourteen children afflicted with evolutive epileptic encephalopathies and still presenting, in spite of heavy anti-epileptic polychemio-therapies, alarming clinical and electrical manifestations. Clonazepam proved to be an efficient contributive factor in the course of a curing process since, in 70% of the cases, it produced quite a visible amelioration. Its efficient action seems to last longer than that of other diazepines since half of their patients have now been treated with it for more than a year with, as a result, a constant clinical and electrical amelioration. As a last point, it appears to be a very useful drug when dealing with type of rebellious epilepsies since, when combined with other benzodiazepines, seldom side-effects and no "crossed resistances" can be observed.
作者研究了口服氯硝西泮且剂量逐渐递增对14名患有进行性癫痫性脑病儿童的影响。尽管进行了大量抗癫痫联合化疗，但这些儿童仍有令人担忧的临床和电生理表现。氯硝西泮在治疗过程中被证明是一个有效的辅助因素，因为在70%的病例中，它产生了相当明显的改善。其有效作用似乎比其他苯二氮䓬类药物持续时间更长，因为现在有一半的患者已经用它治疗了一年多，结果临床和电生理持续改善。最后一点，在治疗难治性癫痫类型时，它似乎是一种非常有用的药物，因为与其他苯二氮䓬类药物联合使用时，很少观察到副作用和“交叉耐药”。
