Rabending G, Fischer W, Arndt R, Böhl I, Brückner H J, Cammann G, Du Chesne H J, Hobusch D, Knaape H H, Müller D, Oettinger B, Rössger B, Rohmann E, Schmidtsdorf R, Vesper J, Zettler H
Psychiatr Neurol Med Psychol (Leipz). 1979 Aug;31(8):472-82.
Clonazepam (Antelepsin) was tested on 179 patients in 8 institutions during a period of 180 days. 169 patients had been unsuccessfully treated with the usual standard medication and were additionally given Antelepsin. Typical absences and attacks of the West and Lennox syndromes yielded best to treatment with the drug, with favorable effects also being produced in cases of partial or focal epilepsy. The most important side-effect was tiredness, other collateral effects being balance disorders, sensations of dizziness, and musuclar weakness. The frequency of side-effects decreased in the course of therapy. In the electroencephalogram there was observed a significant increase in beta waves and a significant decrease in 3 Hz spike and wave complexes.
在180天的时间里，8家机构对179名患者进行了氯硝西泮（安替西平）测试。169名患者接受常规标准药物治疗未取得成功，随后加用了安替西平。典型失神发作以及韦斯特和伦诺克斯综合征的发作对该药物治疗反应最佳，部分性或局灶性癫痫病例也产生了良好效果。最重要的副作用是疲倦，其他附带影响包括平衡障碍、头晕感和肌肉无力。副作用的发生率在治疗过程中有所下降。脑电图显示β波显著增加，3赫兹棘慢复合波显著减少。
