膳食低聚半乳糖可增加正常大鼠和胃切除大鼠的钙吸收。

Dietary galactooligosaccharides increase calcium absorption in normal and gastrectomized rats.

作者信息

dos Santos Elisvânia Freitas, Tsuboi Kathia Hitomi, Araújo Marina Rachel, Andreollo Nelson Adami, Miyasaka Celio Kenji

机构信息

Laboratory of Enzymology and Experimental Carcinogenesis, Campinas State University, Campinas, São Paulo, Brasil.

出版信息

Rev Col Bras Cir. 2011 May-Jun;38(3):186-91. doi: 10.1590/s0100-69912011000300009.

DOI:10.1590/s0100-69912011000300009

PMID:21789458

Abstract

OBJECTIVE

To determine whether the galactooligosaccharide stimulates calcium absorption in partially gastrectomized rats.

METHODS

Animals were submitted to laparotomy (sham-operated control) and partial gastrectomy (Billroth II) in groups of 20. They were fed a control diet (AIN-93M) without galacto-oligosaccharide or a diet containing (galacto-oligosaccharide - 50 g/kg diet) for eight weeks. The animals were divided into four groups: sham-operated and non-gastrectomized with galactooligosaccharide, sham-operated and gastrectomized without galactooligosaccharide. On the final day of the study, whole blood was collected for determination of serum calcium concentration.

RESULTS

In the group with galactooligosaccharides calcium excretion in feces was significantly lower than the group without prebiotics. The apparent absorption of calcium in gastrectomized and normal rats was higher in groups fed with galactooligosaccharide than in the control diet group.

CONCLUSION

The ingestion of galactooligosaccharides prevents osteopenia in partially gastrectomized rats.

摘要

目的

确定低聚半乳糖是否能刺激部分胃切除大鼠的钙吸收。

方法

将动物分成每组20只进行剖腹手术（假手术对照）和部分胃切除术（毕罗Ⅱ式）。它们被喂食不含低聚半乳糖的对照饮食（AIN - 93M）或含低聚半乳糖的饮食（低聚半乳糖 - 50克/千克饮食）八周。动物被分为四组：假手术且未胃切除并喂食低聚半乳糖、假手术且胃切除未喂食低聚半乳糖。在研究的最后一天，采集全血以测定血清钙浓度。