Departamento de Neurofisiología, Laboratorio de Neuroquímica, Instituto Nacional de Rehabilitación, SSA, Calz. México-Xochimilco 289 Col. Arenal de Guadalupe, Delegación Tlalpan, C.P. 14389 México City, Mexico.
Metab Brain Dis. 2011 Sep;26(3):213-20. doi: 10.1007/s11011-011-9254-x. Epub 2011 Jul 26.
The aim of this work was to analyze the effect of oxcarbazepine (OXC) on sleep patterns, "head and body shakes" and monoamine neurotransmitters level in a model of kainic-induced seizures. Adult Wistar rats were administered kainic acid (KA), OXC or OXC + KA. A polysomnographic study showed that KA induced animals to stay awake for the whole initial 10 h. OXC administration 30 min prior to KA diminished the effect of KA on the sleep parameters. As a measure of the effects of the drug treatments on behavior, head and body shakes were visually recorded for 4 h after administration of KA, OXC + KA or saline. The presence of OXC diminished the shakes frequency. 4 h after drug application, the hippocampus was dissected out, and the content of monoamines was analyzed. The presence of OXC still more increased serotonin, 5-hidroxyindole acetic acid, dopamine, and homovanilic acid, induced by KA.
本研究旨在分析奥卡西平（OXC）对红藻氨酸诱导癫痫模型中睡眠模式、“头和身体震颤”以及单胺神经递质水平的影响。成年 Wistar 大鼠给予红藻氨酸（KA）、OXC 或 OXC+KA。多导睡眠图研究显示，KA 诱导动物在最初的 10 小时内保持清醒。OXC 在给予 KA 前 30 分钟给药可减轻 KA 对睡眠参数的影响。作为评估药物治疗对行为影响的一种方法，在给予 KA、OXC+KA 或生理盐水后 4 小时内，通过视觉记录头和身体震颤的频率。OXC 的存在可降低震颤的频率。药物应用 4 小时后，取出海马体，分析单胺类物质的含量。OXC 的存在进一步增加了 KA 诱导的 5-羟色胺、5-羟吲哚乙酸、多巴胺和高香草酸的含量。
