Rheumatic Disease Center, Kurashiki Medical Center, Kurashiki, Japan.
Rheumatol Int. 2012 Aug;32(8):2569-71. doi: 10.1007/s00296-011-2058-9. Epub 2011 Jul 26.
We proposed a method of regional assessment in patients with rheumatoid arthritis. The utility of this method was demonstrated by assessing drug efficacy in patients who received infliximab (n = 31) or tocilizumab (n = 6). Joints were divided into four regions: upper/large, upper/small, lower/large, and lower/small. The total joint index was calculated as follows: the sum of tender and swollen joint counts divided by the number of evaluable joints in each region. At the baseline, the total joint index of the upper/small region was the lowest and that of the lower/large region was the highest compared with other regions. The change in the total joint index from the baseline to the 30-week point (Δ) did not differ among the four regions. There were significant close relations of Δ between the upper/small and the upper/large region and between the lower/small and the lower/large region. This method allows us to focus on a specific region and to compare and contrast among them.
我们提出了一种针对类风湿关节炎患者的区域性评估方法。通过评估接受英夫利昔单抗（n = 31）或托珠单抗（n = 6）治疗的患者的药物疗效，证明了该方法的实用性。关节分为四个区域：大/上肢、大/小上肢、大/下肢和小/下肢。总关节指数的计算方法如下：压痛和肿胀关节数的总和除以每个区域可评估关节的数量。在基线时，与其他区域相比，小/上肢区域的总关节指数最低，大/下肢区域的总关节指数最高。从基线到 30 周点的总关节指数变化（Δ）在四个区域之间没有差异。小/上肢和大/上肢区域以及小/下肢和大/下肢区域之间的Δ具有显著的密切关系。这种方法使我们能够专注于特定区域，并对它们进行比较和对比。
