Bosch X, Ramírez J, Font J, Bombí J A, Ferrer J, Vendrell J, Ingelmo M
Dept of Pathology, Hospital Clinic i Provincial, Barcelona, Spain.
Eur Respir J. 1990 Feb;3(2):234-7.
Neurogenic pulmonary tumours are rare. Neurofibromas are the most common variety and tend to occur in patients with generalized neurofibromatosis, whereas schwannomas arise sporadically in patients who have no evidence of this disorder. A case of solitary benign schwannoma arising in a segmental bronchus is presented, and the published cases reviewed. Microscopically, the tumour had a spindle-shaped cell proliferation with palisade formation in several fields and low cellularity in other areas. The diagnosis was supported by positive immunostaining for S-100 protein and by ultrastructural examination which showed elongated cells surrounded by well-preserved basal lamina and numerous cytoplasmic processes also possessing a basal lamina.
神经源性肺肿瘤较为罕见。神经纤维瘤是最常见的类型，往往发生于患有全身性神经纤维瘤病的患者，而施万细胞瘤则散发性地出现在无此疾病证据的患者中。本文报告了一例发生于节段性支气管的孤立性良性施万细胞瘤病例，并对已发表的病例进行了回顾。显微镜下，肿瘤有梭形细胞增生，在几个区域形成栅栏状结构，其他区域细胞密度较低。S-100蛋白免疫染色阳性及超微结构检查显示细胞细长，周围有保存良好的基底膜，许多细胞质突起也有基底膜，这些均支持该诊断。
