Tamura Masaya, Oda Makoto, Matsumoto Isao, Waseda Ryuichi, Watanabe Go
Department of General and Cardiothoracic Surgery, Kanazawa University School of Medicine, Kanazawa, Japan.
Thorac Cardiovasc Surg. 2012 Mar;60(2):105-10. doi: 10.1055/s-0031-1280068. Epub 2011 Jul 25.
Objectives The aim of this study was to elucidate the optimal parameters for diagnosing false positive (FP) lymph nodes (LNs) in patients with non-small cell lung cancer.Methods We reviewed 292 patients with non-small cell lung cancer (NSCLC). Fluorodeoxyglucose positron emission tomography (FDG-PET) imaging was performed at 1 hour (early) post-FDG injection and repeated 2 hours (delayed) after injection. We analyzed the relationship between the pathology of LNs and the results of PET, and the percent change in the standardized uptake value (%ΔSUV) between the two time-points.Results Eighteen of 46 cases (39.1%) in the FP group showed higher SUVs for their LNs compared with those for primary tumor, whereas 13.2% in the true positive group (p = 0.032) had higher SUVs for their LNs. Thirty-four of 36 cases in the true positive group had %ΔSUV ranging from 0% to 61.5% compared with only 13 of 33 in the FP group. Twenty out of 22 cases (90.9%) where %ΔSUV was over 61.5% or under 0% were considered as FP.Conclusions Patients with higher SUVs for LNs than for primary tumors and patients with extremely high or low %ΔSUVs tended to have FP LNs.
目的 本研究旨在阐明非小细胞肺癌患者中诊断假阳性（FP）淋巴结（LN）的最佳参数。
方法 我们回顾了292例非小细胞肺癌（NSCLC）患者。在注射氟脱氧葡萄糖（FDG）后1小时（早期）进行氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）成像，并在注射后2小时（延迟）重复进行。我们分析了LN的病理学与PET结果之间的关系，以及两个时间点之间标准化摄取值（%ΔSUV）的变化百分比。
结果 FP组46例中的18例（39.1%）其LN的SUV高于原发肿瘤，而真阳性组中13.2%（p = 0.032）的LN具有更高的SUV。真阳性组36例中的34例%ΔSUV范围为0%至61.5%，而FP组33例中只有13例。22例中%ΔSUV超过61.5%或低于0%的20例（90.9%）被认为是FP。
结论 LN的SUV高于原发肿瘤的患者以及%ΔSUV极高或极低的患者往往有FP LN。
