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[输卵管内配子移植:基于62个治疗周期的预后指标分析]

[Intra-tubal gamete transfer: analysis of prognostic indices based on 62 treatment cycles].

作者信息

Fontana-Klaiber H

机构信息

Departement für Frauenheilkunde, Endokrinologie Universitätsspital Zürich.

出版信息

Geburtshilfe Frauenheilkd. 1990 Jan;50(1):33-9. doi: 10.1055/s-2007-1026428.

Abstract

Gamete intrafallopian transfer (GIFT) was applied in 55 couples in 62 treatment cycles. The overall pregnancy rate was 38.7% (24 of 62), the highest incidence of pregnancy being obtained in the group of tubal adhesions (8 [47%] of 17), in cases of multifactorial infertility (7 [44%] of 16) and of unexplained infertility (4 [36%] of 11). The multiple pregnancy rate was 21%, 17% ended in clinical abortions and one (4%) was a tubal pregnancy. Pregnancy was correlated with the number of oocytes transferred: whereas less than or equal to 3 oocytes were replaced in only 1 (4%) of 24 pregnant women, 9 (26%) of 34 non-pregnant women had less than or equal to 3 oocytes transferred (p less than 0.005). On comparing pregnant and non-pregnant women, no significant correlation was found for 1.) the degree of maturity of oocytes transferred, 2.) the percentage of supernumerary oocytes being successfully fertilized in vitro and 3.) the hormonal pattern observed during hyperstimulation with human menopausal gonadotropin.

摘要

62个治疗周期中,对55对夫妇实施了配子输卵管内移植(GIFT)。总体妊娠率为38.7%(62例中有24例),输卵管粘连组妊娠率最高(17例中有8例[47%]),多因素不孕症患者(16例中有7例[44%])以及不明原因不孕症患者(11例中有4例[36%])的妊娠率也较高。多胎妊娠率为21%,17%以临床流产告终,1例(4%)为输卵管妊娠。妊娠与移植卵母细胞数量相关:24例妊娠女性中仅1例(4%)移植的卵母细胞小于或等于3个,而34例未妊娠女性中有9例(26%)移植的卵母细胞小于或等于3个(P<0.005)。比较妊娠和未妊娠女性发现,1.)移植卵母细胞的成熟度、2.)体外成功受精的多余卵母细胞百分比以及3.)用人绝经期促性腺激素进行超促排卵期间观察到的激素模式,均无显著相关性。

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