Tremblay A, Nadeau A, Després J P, St-Jean L, Thériault G, Bouchard C
Physical Activity Sciences Laboratory, Laval University, Quebec, Canada.
Int J Obes. 1990 Jan;14(1):75-84.
The effect of exercise training on glucose and insulin metabolism as well as on resting energy expenditure was investigated in five young men (mean BMI = 27.5 +/- 2.9 (s.d)). Subjects performed cycle-ergometer exercise 6 days/week over a 100 day period and the quantity of daily exercise was calculated to induce a 4.2 MJ/day surplus in energy expenditure during the days of training. As expected, significant weight and fat losses were observed in response to the training program. Exercise training induced a significant reduction in fasting levels and in the responses of insulin to a 4.2 MJ meal or an oral glucose load. Most of the training effects were noted after only 25 days of training. However, a significant decrease in plasma C-peptide concentrations during the oral glucose tolerance test was observed only at the end of the exercise program whereas essentially no change occurred during the first 25 days of training. The resting metabolic rate (RMR) and the thermic effect of food (TEF) were not significantly modified by training. Results show that the reduction in plasma insulin induced by training occurred earlier than that for C-peptide. Moreover, the absence of change in RMR in the presence of a substantial weight loss may represent a beneficial effect of training in comparison to the documented effect of diet-induced weight loss on RMR.
在五名年轻男性（平均体重指数=27.5±2.9（标准差））中研究了运动训练对葡萄糖和胰岛素代谢以及静息能量消耗的影响。受试者在100天的时间里每周6天进行自行车测力计运动，计算出每日运动量，以使训练期间的能量消耗每天有4.2兆焦耳的盈余。正如预期的那样，训练计划导致体重和脂肪显著减轻。运动训练使空腹水平以及胰岛素对4.2兆焦耳餐食或口服葡萄糖负荷的反应显著降低。大多数训练效果在仅25天的训练后就已显现。然而，仅在运动计划结束时观察到口服葡萄糖耐量试验期间血浆C肽浓度显著降低，而在训练的前25天基本没有变化。静息代谢率（RMR）和食物热效应（TEF）并未因训练而发生显著改变。结果表明，训练引起的血浆胰岛素降低比C肽出现得更早。此外，在体重显著减轻的情况下RMR没有变化，与饮食引起的体重减轻对RMR的记录影响相比，这可能代表了训练的有益效果。
