Joshi Deepti, Singh Puja, Zonunfawni Yvonne, Gangane Nitin
Department of Pathology, Mahatma Gandhi Institute of Medical Sciences, Sevagram, India.
Acta Cytol. 2011;55(4):313-8. doi: 10.1159/000326932. Epub 2011 Jul 22.
Metaplastic carcinoma of the breast is a rare malignant neoplasm comprised of ductal, squamous and/or mesenchymal elements in various proportions. Fine needle aspiration diagnosis of this entity is problematic because of its pathological heterogeneity. In this study, we have described the cytomorphological features of histologically confirmed metaplastic carcinomas and also discussed the diagnostic limitations along with a brief review of the literature.
In this observational study, the histology and cytology files of all cases identified as metaplastic carcinomas during the study period (2004-2009) were retrieved. The slides were reviewed for the presence of various elements.
Ten cases were identified as metaplastic carcinomas during the study period. All cases were diagnosed as malignant on cytology. Three cases showed presence of squamous carcinoma cells, 4 showed presence of atypical spindle cells, 2 showed presence of mesenchymal fragments and 1 showed presence of osteoclastic giant cells.
The presence of biphasic tumor cells, atypical spindle cells admixed with poorly differentiated carcinoma cells, squamous carcinoma cells, osteoclastic giant cells and matrix may provide clues for the fine needle aspiration diagnosis of metaplastic carcinomas. However, cytological diagnosis may not be possible in all the cases because of selective sampling of various pathological elements.
乳腺化生性癌是一种罕见的恶性肿瘤，由不同比例的导管、鳞状和/或间充质成分组成。由于其病理异质性，细针穿刺诊断该实体存在问题。在本研究中，我们描述了经组织学证实的化生性癌的细胞形态学特征，并讨论了诊断局限性，同时对文献进行简要回顾。
在这项观察性研究中，检索了研究期间（2004 - 2009年）所有被鉴定为化生性癌病例的组织学和细胞学档案。对玻片进行检查以确定各种成分的存在情况。
在研究期间确定了10例化生性癌病例。所有病例在细胞学上均被诊断为恶性。3例显示有鳞状癌细胞，4例显示有非典型梭形细胞，2例显示有间充质碎片，1例显示有破骨巨细胞。
双相肿瘤细胞、与低分化癌细胞混合的非典型梭形细胞、鳞状癌细胞、破骨巨细胞和基质的存在可能为化生性癌的细针穿刺诊断提供线索。然而，由于各种病理成分的选择性采样，并非所有病例都能进行细胞学诊断。
