Division of Neonatology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.
Neonatology. 2012;101(1):1-7. doi: 10.1159/000323498. Epub 2011 Jul 27.
Posthemorrhagic hydrocephalus (PHH) is a rare but serious outcome among premature babies in the NICU, with consequences including mortality and severe neurodevelopmental disabilities. The causes of PHH are still not entirely understood, and its prevention and treatment are controversial. Various cerebrospinal fluid biomarkers have been studied in infants with PHH in order to recognize the causes, diagnose brain injury, and predict neurodevelopmental outcomes. This systematic review summarizes studies on biomarkers of extracellular matrix activity, fibrinolysis/coagulation, hypoxia/cell death, and inflammation in the cerebrospinal fluid of infants with PHH.
迟发性出血性脑积水（Posthemorrhagic hydrocephalus，PHH）是新生儿重症监护病房（NICU）中早产儿的一种罕见但严重的后果，其后果包括死亡和严重的神经发育障碍。PHH 的病因尚不完全清楚，其预防和治疗存在争议。已经对患有 PHH 的婴儿进行了各种脑脊液生物标志物的研究，以识别病因、诊断脑损伤并预测神经发育结局。本系统综述总结了关于 PHH 婴儿脑脊液中细胞外基质活性、纤维蛋白溶解/凝血、缺氧/细胞死亡和炎症生物标志物的研究。
