通过钯催化的 3-溴-4-对甲苯磺酰氧基-2-吡喃酮的位点选择性铃木-宫浦偶联反应生成多种 2-吡喃酮。

Generation of diverse 2-pyrones via palladium-catalyzed site-selective Suzuki-Miyaura couplings of 3-bromo-4-tosyloxy-2-pyrone.

机构信息

Key Laboratory of Functional Small Organic Molecules, Ministry of Education and College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang, Jiangxi, China.

出版信息

Org Biomol Chem. 2011 Sep 21;9(18):6265-70. doi: 10.1039/c1ob05783a. Epub 2011 Jul 26.

DOI:10.1039/c1ob05783a

PMID:21792436

Abstract

Based on different reactivity of the (pseudo)halide substituents in the 2-pyrone (3-Br and 4-OTs), palladium-catalyzed sequential site-selective Suzuki-Miyaura cross-coupling reactions of 3-bromo-6-methyl-4-tosyloxy-2-pyrone are described, which afford the diverse 2-pyrones in good yields.

摘要

基于 2-吡喃酮（3-Br 和 4-OTS）中（拟）卤化物取代基的不同反应性，描述了钯催化的 3-溴-6-甲基-4-对甲苯磺酰氧基-2-吡喃酮的顺序选择性铃木-宫浦交叉偶联反应，以良好的收率得到了各种 2-吡喃酮。