通过选择性烯烃偶联和区域选择性不对称双羟化反应的方法进行福斯特菌素的汇聚合成。
Convergent synthesis of fostriecin via selective alkene couplings and regioselective asymmetric dihydroxylation.
机构信息
Department of Chemistry, Emory University, Atlanta, Georgia 30322, USA.
出版信息
Org Lett. 2009 Dec 3;11(23):5498-501. doi: 10.1021/ol902365n.
PMID:19902969
Abstract
A highly convergent synthesis of fostriecin is described, featuring sequential palladium-catalyzed Negishi cross couplings to form the C7-C8 bond and C8-methyl bond, followed by late-stage regio- and stereoselective dihydroxylation of C8-C9.
摘要
本文描述了一种高度汇聚的福斯特菌素合成方法，其特征在于连续的钯催化 Negishi 交叉偶联反应形成 C7-C8 键和 C8-甲基键，随后在 C8-C9 进行晚期区域和立体选择性的二羟基化反应。
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