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I148M variant of PNPLA3 confer increased risk for nonalcoholic fatty liver disease not only in European population, but also in Chinese population.

作者信息

Li Xiaohua, Zhao Qingchuan, Wu Kaichun, Fan Daiming

出版信息

Hepatology. 2011 Dec;54(6):2275. doi: 10.1002/hep.24567.

DOI:10.1002/hep.24567
PMID:21793025
Abstract
摘要

相似文献

1
I148M variant of PNPLA3 confer increased risk for nonalcoholic fatty liver disease not only in European population, but also in Chinese population.PNPLA3的I148M变体不仅在欧洲人群中，而且在中国人群中都增加了非酒精性脂肪性肝病的风险。
Hepatology. 2011 Dec;54(6):2275. doi: 10.1002/hep.24567.
2
PNPLA3 I148M variant in nonalcoholic fatty liver disease: demographic and ethnic characteristics and the role of the variant in nonalcoholic fatty liver fibrosis.非酒精性脂肪性肝病中的PNPLA3 I148M变异：人口统计学和种族特征以及该变异在非酒精性脂肪性肝纤维化中的作用
World J Gastroenterol. 2015 Jan 21;21(3):794-802. doi: 10.3748/wjg.v21.i3.794.
3
I148M PNPLA3 variant and progressive liver disease: a new paradigm in hepatology.I148M PNPLA3变异与进行性肝病：肝病学的新范式
Hepatology. 2012 Aug;56(2):1883-9.
4
Circulating triacylglycerol signatures in nonalcoholic fatty liver disease associated with the I148M variant in PNPLA3 and with obesity.非酒精性脂肪性肝病中与 PNPLA3 的 I148M 变异及肥胖相关的循环三酰甘油特征。
Diabetes. 2014 Jan;63(1):312-22. doi: 10.2337/db13-0774. Epub 2013 Sep 5.
5
Methodological concerns about a recent meta-analysis of the influence of the I148M variant of patatin-like phospholipase domain containing 3 on the susceptibility and histological severity of nonalcoholic fatty liver disease.对近期一项关于含3型patatin样磷脂酶结构域的I148M变异体对非酒精性脂肪性肝病易感性和组织学严重程度影响的荟萃分析的方法学关注。
Hepatology. 2011 Jun;53(6):2145; author reply 2146-7. doi: 10.1002/hep.24335. Epub 2011 May 2.
6
Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease.PNPLA3 基因 patatin 样磷脂酶结构域包含 3 基因（PNPLA3）I148M 变体对非酒精性脂肪性肝病易感性和组织学严重程度影响的荟萃分析。
Hepatology. 2011 Jun;53(6):1883-94. doi: 10.1002/hep.24283. Epub 2011 May 14.
7
The PNPLA3 I148M polymorphism is associated with insulin resistance and nonalcoholic fatty liver disease in a normoglycaemic population.载脂蛋白基因 PNPLA3 I148M 多态性与血糖正常人群的胰岛素抵抗和非酒精性脂肪性肝病相关。
Liver Int. 2011 Oct;31(9):1326-31. doi: 10.1111/j.1478-3231.2011.02526.x. Epub 2011 Apr 5.
8
Patatin-Like Phospholipase Domain-Containing 3 I148M Variant Is Associated with Liver Steatosis and Fat Distribution in Chronic Hepatitis B.含Patatin样磷脂酶结构域3的I148M变异与慢性乙型肝炎患者的肝脂肪变性及脂肪分布相关。
Dig Dis Sci. 2015 Oct;60(10):3005-10. doi: 10.1007/s10620-015-3716-7. Epub 2015 May 19.
9
I148M variant in PNPLA3 reduces central adiposity and metabolic disease risks while increasing nonalcoholic fatty liver disease.PNPLA3基因中的I148M变异体可降低中心性肥胖和代谢疾病风险，但会增加非酒精性脂肪性肝病的患病几率。
Liver Int. 2015 Dec;35(12):2537-46. doi: 10.1111/liv.12909. Epub 2015 Jul 23.
10
Patatin-like phospholipase domain-containing 3 I148M affects liver steatosis in patients with chronic hepatitis B.载脂蛋白样磷脂酶结构域蛋白 3 I148M 影响慢性乙型肝炎患者的肝脏脂肪变性。
Hepatology. 2013 Oct;58(4):1245-52. doi: 10.1002/hep.26445. Epub 2013 Aug 6.

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Viruses. 2023 Aug 12;15(8):1724. doi: 10.3390/v15081724.
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Genetic Polymorphisms and Diversity in Nonalcoholic Fatty Liver Disease (NAFLD): A Mini Review.非酒精性脂肪性肝病（NAFLD）中的基因多态性与多样性：一篇综述短文
Biomedicines. 2022 Dec 30;11(1):106. doi: 10.3390/biomedicines11010106.
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Genetics Is of the Essence to Face NAFLD.遗传学对于应对非酒精性脂肪性肝病至关重要。
Biomedicines. 2021 Sep 30;9(10):1359. doi: 10.3390/biomedicines9101359.
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and polymorphisms in Brazilian patients with nonalcoholic fatty liver disease.以及巴西非酒精性脂肪性肝病患者的基因多态性。
World J Hepatol. 2020 Oct 27;12(10):792-806. doi: 10.4254/wjh.v12.i10.792.
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Nonalcoholic fatty liver disease and alcohol-related liver disease: From clinical aspects to pathophysiological insights.非酒精性脂肪性肝病和酒精性肝病：从临床方面到病理生理学见解。
Clin Mol Hepatol. 2020 Oct;26(4):728-735. doi: 10.3350/cmh.2020.0202. Epub 2020 Oct 1.
6
APOC3 rs2070666 Is Associated with the Hepatic Steatosis Independently of PNPLA3 rs738409 in Chinese Han Patients with Nonalcoholic Fatty Liver Diseases.在中国汉族非酒精性脂肪性肝病患者中，载脂蛋白C3基因rs2070666与肝脂肪变性相关，且独立于帕他汀样磷脂酶域蛋白3基因rs738409。
Dig Dis Sci. 2016 Aug;61(8):2284-2293. doi: 10.1007/s10620-016-4120-7. Epub 2016 Apr 8.
7
Shifts in dietary carbohydrate-lipid exposure regulate expression of the non-alcoholic fatty liver disease-associated gene PNPLA3/adiponutrin in mouse liver and HepG2 human liver cells.膳食碳水化合物-脂质暴露的变化调节非酒精性脂肪性肝病相关基因 PNPLA3/脂联素在小鼠肝脏和 HepG2 人肝细胞中的表达。
Metabolism. 2014 Oct;63(10):1352-62. doi: 10.1016/j.metabol.2014.06.016. Epub 2014 Jun 21.
8
Genetic variants in PNPLA3 and risk of non-alcoholic fatty liver disease in a Han Chinese population.载脂蛋白 PNPLA3 基因变异与汉族人群非酒精性脂肪性肝病的风险。
PLoS One. 2012;7(11):e50256. doi: 10.1371/journal.pone.0050256. Epub 2012 Nov 30.
9
Genetic variant I148M in PNPLA3 is associated with the ultrasonography-determined steatosis degree in a Chinese population.载脂蛋白基因 I148M 变异与中国人群超声检测的脂肪变程度相关。
BMC Med Genet. 2012 Nov 23;13:113. doi: 10.1186/1471-2350-13-113.
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Glucokinase links Krüppel-like factor 6 to the regulation of hepatic insulin sensitivity in nonalcoholic fatty liver disease.葡萄糖激酶将 Krüppel 样因子 6 与非酒精性脂肪性肝病中肝脏胰岛素敏感性的调节联系起来。
Hepatology. 2012 Apr;55(4):1083-93. doi: 10.1002/hep.24793. Epub 2012 Mar 1.