heimiol A、hopeahainol D 的全合成及刚性类似物。
Total syntheses of heimiol A, hopeahainol D, and constrained analogues.
机构信息
Department of Chemistry, Columbia University, Havemeyer Hall, 3000 Broadway, New York, NY 10027, USA.
出版信息
Angew Chem Int Ed Engl. 2011 Sep 5;50(37):8629-33. doi: 10.1002/anie.201103575. Epub 2011 Jul 26.
Abstract
UNLABELLED
[Image: see text]
IDSI TO THE RESCUE
Use of a carefully designed cascade process empowered by the unique iodonium-reagent IDSI [(EtSI)Cl•SbCl] provided the means to construct the entire [3.2.2]-bicyclic core of both targets in a single, stereocontrolled operation. Use of strain energies assisted in the completion of the natural products, with the overall strategy proving applicable as well to the preparation of a number of unique [3.2.1]-dimeric and highly strained resveratrol-based compounds.
摘要
未标记
[图像：见正文]
IDSI 来救援：巧妙设计的级联过程，加上独特的碘鎓试剂 IDSI [(EtSI)Cl•SbCl]，为在单个立体控制操作中构建两个目标的整个 [3.2.2]-双环核心提供了手段。应变能的使用有助于完成天然产物的合成，整体策略同样适用于多种独特的[3.2.1]-二聚体和高度应变的白藜芦醇类化合物的制备。
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