State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province and Department of Chemistry, Lanzhou University, Lanzhou 730000, People's Republic of China.
ACS Appl Mater Interfaces. 2011 Aug;3(8):3215-23. doi: 10.1021/am2007189. Epub 2011 Aug 5.
Covalent functionalization of azide-modified SiO(2) with well-defined, alkyne-terminated poly(N-isopropylacrylamide) was accomplished by the Cu(I)-catalyzed [3 + 2] Huisgen cycloaddition. The alkyne-terminated RAFT chain transfer agent was first synthesized, and then the alkyne-terminated thermoresponsive poly(N-isopropylacrylamide) (PNIPAM) with different molecular weights were synthesized by the RAFT of NIPAM monomer. The polymerization kinetics and the evolution of number-average molecular weights (M(n)), and polydispersities (M(w)/M(n)), with monomer conversions were investigated. A copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) "grafting to" method was used to attach thermoresponsive polymers onto the exterior surface of SiO(2) nanoparticles which produced relatively high grafting density. The as-synthesized hybrid nanoparticles showed thermoresponsive behavior and were characterized by FTIR, XPS, TGA, DLS, and TEM, etc.
通过铜 (I) 催化的 [3 + 2] Huisgen 环加成反应，实现了叠氮修饰的 SiO(2)与具有明确炔端的聚 (N-异丙基丙烯酰胺) 的共价功能化。首先合成了炔端的 RAFT 链转移剂，然后通过 NIPAM 单体的 RAFT 合成了具有不同分子量的炔端温敏性聚 (N-异丙基丙烯酰胺) (PNIPAM)。研究了聚合动力学以及单体转化率时数均分子量 (M(n)) 和多分散性 (M(w)/M(n)) 的演变。使用铜 (I) 催化的叠氮-炔环加成 (CuAAC)“接枝到”方法将温敏聚合物附着到 SiO(2)纳米粒子的外表面上，从而产生相对高的接枝密度。所合成的杂化纳米粒子表现出温敏行为，并通过 FTIR、XPS、TGA、DLS 和 TEM 等进行了表征。
