The University of Queensland, UQ Centre for Clinical Research, Queensland, Australia.
Addiction. 2012 Feb;107(2):241-7. doi: 10.1111/j.1360-0443.2011.03511.x. Epub 2011 Jul 27.
The compulsive use of dopamine replacement therapy (DRT) or dopamine dysregulation syndrome (DDS) is one of the behavioural disturbances reported in some patients with Parkinson's disease (PD) and other disorders who are receiving DRT. We draw this phenomenon to the attention of the addiction field as a topic deserving of more systematic study. We outline: the clinical features, epidemiology and clinical correlates of the disorder; the unresolved issues in its definition and diagnosis; and its potential relevance to neurobiological models of psychostimulant addiction. We argue that compulsive DRT use may provide a useful model for drug addiction, while advancing our understanding of the neurobiology of addiction and improving the management of PD patients with the disorder.
多巴胺替代疗法（DRT）或多巴胺失调综合征（DDS）的强制性使用是一些接受 DRT 的帕金森病（PD）和其他疾病患者报告的行为障碍之一。我们提请成瘾领域注意这一现象，认为这是一个值得更系统研究的主题。我们概述了该疾病的临床特征、流行病学和临床相关性；其定义和诊断方面尚未解决的问题；以及它对精神兴奋剂成瘾的神经生物学模型的潜在相关性。我们认为，强制性 DRT 使用可能为药物成瘾提供一个有用的模型，同时增进我们对成瘾神经生物学的理解，并改善患有该疾病的 PD 患者的管理。
